Scientists have caught a glimpse of the elusive toxic form of the Alzheimer's molecule, during its attempt to bore into the outer covering of a cell decoy, using a new method involving laser light and fat-coated silver nano-particles.
Bio & Medicine
Aug 25, 2015
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25
Researchers have shown that aggregation of amyloid-beta, one of two key proteins implicated in Alzheimer's disease, causes cells to overheat and "fry like eggs."
Biochemistry
May 31, 2022
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252
(PhysOrg.com) -- Which modules of the tau protein, in neurons of Alzheimer disease patients, may act in a destructive manner were investigated by researchers from the Max Planck Institute for Biophysical Chemistry (Göttingen) ...
Feb 17, 2009
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0
A probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide—the kind suspected of causing Alzheimer's disease—has identified a specific binding site on the protein that could facilitate ...
Biochemistry
Oct 19, 2017
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255
Scientists from Rice University are using fluorescence lifetime to shed new light on a peptide associated with Alzheimer's disease, which the Centers for Disease Control and Prevention estimates will affect nearly 14 million ...
Biochemistry
Jan 25, 2023
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32
Inside a living cell, proteins and other molecules are often tightly packed together. These dense clusters can be difficult to image because the fluorescent labels used to make them visible can't wedge themselves in between ...
Bio & Medicine
Aug 29, 2022
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138
More than half of all cases of dementia in the elderly can be attributed to Alzheimer's disease. Despite vast research efforts, an effective therapy has not been developed, and treatment consists of dealing with the symptoms. ...
Biochemistry
Jan 12, 2012
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0
Scientists at UC Santa Barbara and several other institutions have found laboratory evidence that a cluster of peptides may be the toxic agent in Alzheimer's disease. Scientists say the discovery may lead to new drugs for ...
Biochemistry
Jul 1, 2009
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0
A metallic molecule being studied at Rice University begins to glow when bound to amyloid protein fibrils of the sort implicated in Alzheimer's disease. When triggered with ultraviolet light, the molecule glows much brighter, ...
Biochemistry
Jul 7, 2016
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12
In the past few years, despite the best efforts of scientists and medical researchers, drug after drug designed to slow or stop the progression of Alzheimer's disease has failed in clinical trials. Some had no effect on the ...
Biochemistry
Feb 22, 2016
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136
Amyloid beta (Aβ or Abeta) is a peptide of 39–43 amino acids that appear to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease. Aβ also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy. These plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as prions associated with protein misfolding diseases. Research on laboratory rats suggest that the two-molecule, soluble form of the peptide is a causative agent in the development of Alzheimer's and that the two-molecule form is the smallest synaptotoxic species of soluble amyloid beta oligomer
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