A strategy to refine genetic base editors
Want to keep the riffraff out of the gene pool party? Sneak in and slam the gate before they arrive.
Biotechnology
Nov 11, 2021
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36
News tagged with base editors
New gene-editing technique offers scientists ability to 'turn on' enzymes that cause DNA base mutations
Targeted mutations to the genome can now be introduced by splitting specific mutator enzymes and then triggering them to reconstitute, according to research from the Perelman School of Medicine at the University of Pennsylvania. ...
Biochemistry
Oct 28, 2021
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674
Using CRISPR to lower cholesterol levels in monkeys
A team of researchers from Verve Therapeutics and the Perelman School of Medicine at the University of Pennsylvania has developed a CRISPR gene-editing technique that lowered the levels of cholesterol in the blood of test ...
New understanding of CRISPR-Cas9 tool could improve gene editing
Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic ...
Biotechnology
Jul 30, 2020
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425
Researchers develop new cytosine base editors with high specificity and precision
Base editors, which enable production of highly efficient targeted point mutations in genomic DNA without causing double-stranded DNA breaks, hold great promise for gene therapy in human disease and trait improvement in crop ...
Biotechnology
Jul 27, 2020
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5
'Bystander' cytosines meet their match in gene-editing technique
Biomolecular engineers at Rice University have found a C-worthy technique that dramatically enhances the accuracy of gene editing.
Molecular & Computational biology
Jul 15, 2020
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108
Precision genome editing enters the modern era
CRISPR has sparked a renaissance in genome editing. Now, next-generation CRISPR technologies let scientists modify the genome more efficiently and precisely than before. Such tools could one day serve as therapeutics, but ...
Biotechnology
Jun 15, 2020
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33
New machine learning model predicts which base editor performs best to repair thousands of disease-causing mutations
Gene editing technology is getting better and growing faster than ever before. New and improved base editors—an especially efficient and precise kind of genetic corrector—inch the tech closer to treating genetic diseases ...
Biotechnology
Jun 12, 2020
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97
Scientists optimize prime editing for rice and wheat
Many genetic and breeding studies have shown that point mutations and indels (insertions and deletions) can alter elite traits in crop plants. Although nuclease-initiated homology-directed repair (HDR) can generate such changes, ...
Biotechnology
Mar 16, 2020
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32
New CRISPR base-editing technology slows ALS progression in mice
With a new CRISPR gene-editing methodology, scientists from the University of Illinois at Urbana-Champaign inactivated one of the genes responsible for an inherited form of amyotrophic lateral sclerosis—a debilitating and ...
Biotechnology
Feb 24, 2020
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379
