Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic ...
Biotechnology
Jul 30, 2020
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425
Targeted mutations to the genome can now be introduced by splitting specific mutator enzymes and then triggering them to reconstitute, according to research from the Perelman School of Medicine at the University of Pennsylvania. ...
Biochemistry
Oct 28, 2021
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674
Gao Caixia's group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has pioneered the use of artificial intelligence (AI)-assisted methods to discover novel deaminase proteins with ...
Biotechnology
Jun 27, 2023
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16
A team of researchers from Verve Therapeutics and the Perelman School of Medicine at the University of Pennsylvania has developed a CRISPR gene-editing technique that lowered the levels of cholesterol in the blood of test ...
Gene therapy using CRISPR/Cas9 gene editing is currently in clinical trials around the world for a variety of diseases. A report from Boston Children's Hospital, published June 27 in Nature Communications, warns of a potential, ...
Cell & Microbiology
Jul 6, 2022
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219
Researchers from the Center for Genome Engineering within the Institute for Basic Science developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED. TALEDs are base editors ...
Biotechnology
Apr 25, 2022
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44
A Massachusetts General Hospital (MGH) research team reports that several of the recently developed CRISPR base editors, which create targeted changes in a single DNA base, can induce widespread off-target effects in RNA, ...
Biotechnology
Apr 17, 2019
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189
An international team of researchers has succeeded in making 13,200 edits to a single cell—and the cell survived. In their paper uploaded to the bioRxiv preprint server, the team describes the edits they made, how they ...
A team from the Broad Institute of MIT and Harvard has developed a new CRISPR genome-editing approach by combining two of the most important proteins in molecular biology—CRISPR-Cas9 and a reverse transcriptase—into a ...
Biotechnology
Oct 21, 2019
2
339
A team of researchers with the Broad Institute of Harvard and MIT has found evidence showing that using base editors can lead to unexpected RNA cellular edits. In their paper published in the journal Science Advances, the ...
