Water—which makes up the majority of every cell in the body—plays a key role in how proteins, including those associated with Parkinson's disease, fold, misfold, or clump together, according to a new study.
Biochemistry
Nov 15, 2022
0
44
It's a paradox: Life needs water to survive, but a world full of water can't generate the biomolecules that would have been essential for early life. Or so researchers thought.
Evolution
Nov 3, 2022
0
3
A vast number of biological reactions occur inside cells, generating various byproducts. Some of these can be highly reactive molecules, and if they build up inside cells they can cause stress and damage. One class of these ...
Cell & Microbiology
Oct 31, 2022
0
1130
Scientists at EPFL have determined how a protein that is critical in our first line of immune defense is regulated in the cell to prevent autoinflammatory diseases.
Cell & Microbiology
Oct 25, 2022
0
33
Over the past two years, machine learning has revolutionized protein structure prediction. Now, three papers in Science describe a similar revolution in protein design.
Molecular & Computational biology
Sep 15, 2022
0
2632
This story begins several billion years ago. There's only chemistry, no biology—that is, plenty of chemical compounds exist on Earth, but life hasn't yet emerged. Then, among myriads of randomly self-assembled chemical ...
Evolution
Sep 14, 2022
1
832
In the summer and fall of 2019, some cancer patients experienced interruptions in their treatment. The reason was a shortage of the drugs vinblastine and vincristine, essential chemotherapeutic medicines for several types ...
Biotechnology
Sep 1, 2022
0
106
Drug molecules and biofuels can be made to order by living cell factories, where biological enzymes do the job. Now, researchers at Chalmers University of Technology have developed a computer model that can predict how fast ...
Biochemistry
Aug 31, 2022
0
452
CEST researchers developed a new machine learning approach based on a low-energy latent space (LOLS) and density functional theory (DFT) to search for molecular conformers.
Analytical Chemistry
Aug 25, 2022
0
26
A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type ...
Biochemistry
Aug 10, 2022
0
59
