Lysosome to mitochondria communication regulates longevity

As people get older, they often feel less energetic, mobile or active. This may be due in part to a decline in mitochondria, the tiny powerhouses inside of our cells, which provide energy and regulate metabolism. In fact, ...

It takes a neutron beam to find a proton

Understanding the behavior of proteins and enzymes is key to unlocking the secrets of biological processes. The atomic structures of proteins are generally investigated using X-ray crystallography; however, the precise information ...

Ancient origins of allosteric activation in the oldest kinases

One of the key features in the evolution of more complex organisms is the emergence of allosteric regulation. Allostery is a process by which a protein's activity can be modulated by binding an effector molecule distal to ...

Resurrected protein reveals structure of important enzyme

To disarm toxic substances, many organisms including humans possess enzymes called flavin-containing monooxygenases (FMOs). Despite their importance, the structure of the enzymes has not been resolved, as the protein is too ...

Designing and repurposing cell receptors

EPFL scientists have developed a computational method modeling and designing protein allostery that allows the accurate and rational engineering and even repurposing of cell receptors. The method can be a significant tool ...

Growing HCA crystals

Zoë Fisher and Katarina Koruza from the ESS Deuteration and Macromolecular Crystallization (DEMAX) Support lab and Lund University have been using vapor diffusion methods to grow large protein crystals for neutron techniques ...

A 'biomultimeter' to measure RNA and protein production in real-time

Builders of genetic circuits face the same quandary as builders of digital circuits: testing their designs. Yet unlike bioengineers, engineers have a simple and universal testing tool—the multimeter—that they can touch ...

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