Search results for CRISPR

Cell & Microbiology Mar 14, 2024

Researchers reveal dual-function mechanism of bacteriophage-derived protein AcrIIA15

In response to the efficient attacks of the host CRISPR-Cas system, bacteriophages have evolved various resistance strategies, including encoding anti-CRISPR (Acr) proteins. Since their initial discovery in 2013, over a hundred ...

Biotechnology Mar 14, 2024

It's hearty, it's meaty, it's mold: Hacking the genome of fungi for smart foods of the future

With animal-free dairy products and convincing vegetarian meat substitutes already on the market, it's easy to see how biotechnology can change the food industry. Advances in genetic engineering are allowing us to harness ...

Bio & Medicine Mar 12, 2024

'GPS nanoparticle' platform precisely delivers therapeutic payload to cancer cells

A newly developed "GPS nanoparticle" injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State. They tested ...

Biotechnology Mar 7, 2024

CRISPRlnc: New lncRNA-specific SgRNA design method proposed

Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts. Currently, CRISPR/Cas9 is a promising RNA-guided genome editing technology consisting of a Cas9 nuclease and a single-guide RNA (sgRNA). Considering the significant ...

Biotechnology Mar 7, 2024

Natural tech for 'dimming' genes brings transformative potential to agriculture

Until the 1992 advent of a tomato that could delay softening, the fruit was picked green to withstand shipping. The delayed-softening trait was an example of the gene-silencing technique RNA interference, RNAi, before the ...

Plants & Animals Feb 26, 2024

Using CRISPR gene editing to prevent pigs from getting blue-ear pig disease

A team of bio-scientists affiliated with a host of institutions across the U.S. has developed a gene editing technique to produce newborn pigs immune to porcine reproductive and respiratory syndrome, also known as blue-ear ...

Molecular & Computational biology Feb 22, 2024

CRISPR/Cas9-mediated targeted mutagenesis of inulin biosynthesis in rubber dandelion

Researchers have leveraged the power of the CRISPR/Cas9 genome editing system to enhance natural rubber production in rubber dandelion (Taraxacum kok-saghyz). The CRISPR system's efficiency and precision offer a promising ...

Biotechnology Feb 22, 2024

Chromatin accessibility: A new avenue for gene editing

In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its ...

Cell & Microbiology Feb 21, 2024

A new RNA editing tool could enhance cancer treatment

Cell therapies for cancer can be potentially enhanced using a CRISPR RNA-editing platform, according to a new study published Feb. 21 in Cell.

Biotechnology Feb 20, 2024

Junk DNA in birds may hold key to safe, efficient gene therapy

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job of knocking out genes to cure hereditary disease. But it's still not possible to insert whole genes ...

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