Search results for organ-on-a-chip

Analytical Chemistry Feb 8, 2017

Scientists create organs-on-chips for large-scale drug screening

Led by UCI professor of molecular biology & biochemistry Christopher C.W. Hughes, the research team successfully established multiple vascularized micro-organs on an industry-standard 96-well plate. Hughes and the study's ...

Analytical Chemistry Jan 6, 2023

Investigating the intestinal transport of mercury ions with a gut-on-a-chip device

The transport of mercury ions across intestinal epithelial cells can be studied for toxicology assessments by using animal models and static cell cultures. However, the concepts do not reliably replicate conditions of the ...

Analytical Chemistry Mar 20, 2022

'Worm-on-a-chip' device could someday help diagnose lung cancer

Dogs can use their incredible sense of smell to sniff out various forms of cancer in human breath, blood and urine samples. Similarly, in the lab a much simpler organism, the roundworm C. elegans, wriggles its way toward ...

Biotechnology Jun 17, 2019

Inducing an osteoarthritic (OA) phenotype in a cartilage-on-a-chip (COC) model

In an aging population, the social impact of osteoarthritis (OA) can dramatically increase to become the most common musculoskeletal disease. However, at present, therapies are limited to palliative treatments or surgical ...

Environment Mar 16, 2016

Coral on a chip cracks coral mysteries

We know that human-induced environmental changes are responsible for coral bleaching, disease, and infertility. Loss of the world's stony coral reefs - up to 30% in the next 30 years, according to some estimates - will mean ...

General Physics Apr 22, 2011

Optical microscope without lenses produces high-resolution 3-D images on a chip

(PhysOrg.com) -- UCLA researchers have redefined the concept of a microscope by removing the lens to create a system that is small enough to fit in the palm of a hand but powerful enough to create three-dimensional tomographic ...

Analytical Chemistry Mar 27, 2020

Using ordinary tape, researchers make chip that could speed up drug development

With ordinary double-sided tape, researchers in Sweden assembled a chip-based model of a human gut, and then fed it chili peppers to prove it works. The technique could dramatically lower cost barriers for labs that test ...

Analytical Chemistry Apr 4, 2012

IBN's 'fish and chips' may help accelerate drug discovery

A cheaper, faster and more efficient platform for preclinical drug discovery applications has been invented by scientists at the Institute of Bioengineering and Nanotechnology (IBN), the world’s first bioengineering ...

Biotechnology Mar 3, 2020

Advances in computer modeling, protein development propel cellular engineering

Recent advances in bioengineering and computational modeling have given researchers the ability to examine complex biological processes with molecular-level detail.

Biotechnology May 13, 2019

Human gut microbiome physiology can now be studied in vitro using Organ Chip technology

The human microbiome, the huge collection of microbes that live inside and on our body, profoundly affects human health and disease. The human gut flora in particular, which harbor the densest number of microbes, not only ...

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