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Biochemistry Oct 13, 2023

Targeting a coronavirus ion channel could yield new COVID-19 drugs

The genome of the SARS-CoV-2 virus encodes 29 proteins, one of which is an ion channel called E. This channel, which transports protons and calcium ions, induces infected cells to launch an inflammatory response that damages ...

Cell & Microbiology Sep 27, 2023

Quorum sensing circuit controls mosquito commensal gut colonization via OMV-mediated aggregation

Prof. Wang Sibao from Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences and his colleagues have revealed that quorum sensing-activated phenylalanine metabolism drives outer membrane vesicles ...

Biotechnology Sep 25, 2023

Solid-state NMR unveils fluoride ion channel permeation mechanism

A research team led by Shi Chaowei from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) has adapted the fluoride ion channel protein Fluc-Ec1 combined with deuterium substitution ...

Plants & Animals Sep 19, 2023

Study finds iron oxide nanoparticles are useful for medicinal plant sustainability under toxic metal conditions

Metal(loid) toxicity severely inhibits plant growth and development, thereby affecting yield and quality. It is crucial to seek favorable measures to improve plant survival under toxic metal(loid) conditions.

Molecular & Computational biology Aug 4, 2023

MHZ9 modulates ethylene signaling at translational level in rice

Ethylene is a versatile gaseous plant hormone that plays an important role in rice growth, development, and environmental adaptation. Translational control allows the mRNA to be translated in an mRNA-selective, signal-responsive, ...

Analytical Chemistry Aug 2, 2023

Steric zipper interactions in artificial crystalline peptide β-sheets

Steric zippers are a specific type of hydrophobic packing structure that form between two adjacent layers of peptide β-sheets in amyloid and similar fibrils. These structures play a crucial role in the stability and propagation ...

Biotechnology Jul 21, 2023

New sensor mimics cell membrane functions, may enable screening of hard-to-diagnose cancers

Drawing inspiration from natural sensory systems, an MIT-led team has designed a novel sensor that could detect the same molecules that naturally occurring cell receptors can identify.

Biochemistry Jul 17, 2023

New stapling method solves floppy peptide problem

In a cutting-edge discovery, published in the Journal of the American Chemical Society, Florey scientists have solved a long-standing problem: the need for an affordable, simple way to make peptide-based drugs that hold their ...

Ecology Jun 28, 2023

Diatom / bacteria symbiosis in the open ocean explored

A study published in PNAS Nexus explores the genetic expression of a photosynthetic symbiont that lives inside an abundant marine organism. Marine diatoms are responsible for one-fifth of global photosynthesis. Many are coastal, ...

Cell & Microbiology May 23, 2023

Engineers create bacteria that can synthesize an unnatural amino acid

In a study recently published in Nature Chemical Biology, researchers focused on para-nitro-L-phenylalanine (pN-Phe), a non-standard amino acid that is neither one of the twenty standard amino acids nor observed in nature. ...

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