As they grow, solid tumors surround themselves with a thick, hard-to-penetrate wall of molecular defenses. Getting drugs past that barricade is notoriously difficult. Now, scientists at UT Southwestern have developed nanoparticles ...
The molecular tool CRISPR-Cas9 can be used to treat inherited blood disorders, but this may cause unintended genetic alterations. A team led by MDC researchers Klaus Rajewsky and Van Trung Chu has now presented an approach ...
The origins of our blood may not be quite what we thought. Using cellular "barcoding" in mice, a groundbreaking study finds that blood cells originate not from one type of mother cell, but two, with potential implications ...
The oysters, as the representative bivalve mollusk, are widely distributed and support major aquaculture and fishery industries worldwide. However, oysters are still at an early stage of domestication.
Friend or foe? Immune systems constantly face this question. They must recognize and clear foreign invaders without eliciting autoimmunity. Prokaryotic CRISPR-Cas systems recognize invaders based on genetic sequence. But ...
The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including Whitehead Institute, and was finally ...
A trio of researchers at the University of California, Berkeley, has found that the protein Cas12c can provide antiviral immunity for bacteria without the need to cut DNA. In their paper published in the journal Molecular ...
During the last few years, CRISPR has grabbed headlines for helping treat patients with conditions as varied as blindness and sickle cell disease. However, long before humans co-opted CRISPR to fight genetic disorders, bacteria ...
The appendages that protrude from a mosquito's head hold the sensory systems that account for nearly all of its ability to detect and respond to a wide range of chemical signals that are critical for its reproduction and ...
Last year, researchers at MIT's McGovern Institute for Brain Research discovered and characterized Cas7-11, the first CRISPR enzyme capable of making precise, guided cuts to strands of RNA without harming cells in the process. ...
