Scientists make diseased cells synthesize their own drug

In a new study that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute (TSRI) have adapted a chemical approach to turn diseased cells into unique manufacturing ...

Biologists show inner workings of cellular 'undertaker'

One of a cell's most important responsibilities is to break down and recycle proteins that are no longer needed or endanger the cell. This task is carried out by a cellular nanomachine called the proteasome.

Scientists watch membrane fission in real time

Researchers at The Scripps Research Institute have solved one of biology's neatest little tricks: they have discovered how a cell's outer membrane pinches a little pouch from itself to bring molecules outside the cell inside—without ...

New probes quantify folded and misfolded protein levels in cells

Scientists at The Scripps Research Institute (TSRI) have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest ...

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