Cancer patients fear the possibility that one day their cells might start rendering many different chemotherapy regimens ineffective. This phenomenon, called multidrug resistance, leads to tumors that defy treatment.
Biochemistry
Mar 2, 2015
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43
Two prominent origin-of-life chemists have published a new hypothesis for how the first sugars—which were necessary for life to evolve—arose on the early Earth.
Biochemistry
Apr 13, 2023
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83
A new study led by researchers at The Scripps Research Institute (TSRI) and the University of California (UC), San Diego School of Medicine shows that certain stem cell culture methods are associated with increased DNA mutations. ...
Cell & Microbiology
Feb 25, 2015
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70
A good night's sleep does more than prevent yawning. New research from The Scripps Research Institute (TSRI) shows that two proteins critical for maintaining healthy day-night cycles also protect against mutations that could ...
Cell & Microbiology
Mar 10, 2015
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48
(Phys.org) —Proteins, the workhorses of the body, can have more than one function, but they often need to be very specific in their action or they create cellular havoc, possibly leading to disease.
Cell & Microbiology
Apr 29, 2013
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0
Using clever chemistry, a Scripps Research team has pinpointed the enzyme target of a drug group that stops the progression of the devastating disease Friedreich's ataxia in mice and may do the same for humans. The findings, ...
Biochemistry
Sep 25, 2009
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0
Scripps Research chemists have accomplished a long-elusive feat in synthetic chemistry: the invention of a broadly useful method for constructing "gamma chiral centers" on simple starting compounds called carboxylic acids. ...
Biochemistry
May 17, 2024
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44
Many proteins work like Swiss Army knives, fitting multiple functions into their elaborately folded structures. A bit mysteriously, some proteins manage to multitask even with structures that are unfolded and floppy—"intrinsically ...
Cell & Microbiology
Jun 19, 2013
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0
A team at The Scripps Research Institute has detailed the structure of a member of the only remaining class of multidrug resistance transporters left to be described. The work has implications for combating dangerous antibiotic ...
Cell & Microbiology
Sep 22, 2010
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0
Scientists at The Scripps Research Institute (TSRI) have found that an enzyme best known for its fundamental role in building proteins has a second major function: to protect DNA during times of cellular stress.
Biotechnology
Oct 2, 2014
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