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Chemists develop new method for making gamma chiral centers on simple carboxylic acids

Chemists develop new method for making gamma chiral centers on simple carboxylic acids
Preparation of bidentate TZ-pyridone ligands. Credit: Science (2024). DOI: 10.1126/science.ado1246

Scripps Research chemists have accomplished a long-elusive feat in synthetic chemistry: the invention of a broadly useful method for constructing "gamma chiral centers" on simple starting compounds called carboxylic acids. The method significantly extends the ability of chemists to build and modify complex pharmaceutical molecules and other valuable chemical products.

The paper, "Enantioselective Remote Methylene C−H (Hetero)Arylation of Cycloalkane Carboxylic Acids," has been published in the journal Science.

The term chiral refers to a type of asymmetry that allows some chemical compounds to exist in left-handed and right-handed forms. Often, only one of these forms has the desired biochemical activity, but for synthetic chemists, stereoselective reactions—those that yield just the desired form—are almost always challenging.

The new method enables what had been impossible except in narrow cases: creating a center of chiral asymmetry at a hard-to-reach position called the "gamma" position on a cyclic carboxylic acid.

"This approach offers unprecedented and relatively easy access to a broad set of chiral carbocycles that are privileged structures for pharma industry drug discovery programs," says study senior author Jin-Quan Yu, Ph.D., Frank and Bertha Hupp Professor of Chemistry and Bristol Myers Squibb Endowed Chair in Chemistry at Scripps Research.

The co-first authors were Tao Zhang, Ph.D., and Zi-Yu Zhang, Ph.D., both postdoctoral research associates in the Yu lab.

A potentially valuable but elusive method

The development of small molecule pharmaceuticals or other chemical products typically involves the construction of many hundreds or thousands of compounds, each representing a variation on a central structural theme. Once these "libraries" of compounds are constructed, they are methodically tested for the desired biological or chemical activity; in this way, developers can zero in on the best compound for further refinement.

Naturally, in constructing these libraries and in making more refined variants, chemists would like to have easy and versatile techniques for building and modifying molecules. But while their tools have greatly improved over the years, some types of molecular transformation have remained essentially undoable, despite the obvious value they would have.

Gamma chiral center construction using readily available has been one of these, defying the efforts of prominent labs.

The Yu lab's success hinged on the development of special "ligand" molecules containing both oxazoline and pyridone structural elements. Ligand molecules help bring the reaction catalyst to the right spot on the initial compound.

In this case, they fasten to one point on the starting carboxylic acid—which contains a ring of mostly carbon atoms—and direct a bond-breaking palladium atom to the distant gamma position on the other side of the ring. The effect is to remove a hydrogen atom from the backbone carbon atom at the targeted spot, allowing a new cluster of atoms to bond to the carbon—thus adding complexity to the molecule in a precise way.

This type of reaction is called a "C-H activation," and over the past decade, Yu and his team have reported similar C-H activation methods for constructing chiral centers at "alpha" and "beta" positions on carboxylic acids.

The chemists demonstrated the power and versatility of their new method by using it to make gamma chiral centers on a wide variety of relatively simple carboxylic acid starting compounds containing rings of from five to eight carbon atoms.

In one case, they achieved a single-step synthesis of a chiral version of a cancer drug molecule called an HDAC inhibitor—whose standard, patented synthesis method requires 10 steps and a costly separation to obtain pure samples of the left-handed or right-handed form.

The team also used the new technique to add complexity to existing drug molecules, including the steroid hormone pregnenolone.

Finally, the chemists showed they could use their new approach sequentially on a starting molecule to construct three chiral centers—including a very challenging "delta" chiral center.

The Yu lab is now working to extend the new approach so it can be used for making other types of chiral molecules.

More information: Tao Zhang et al, Enantioselective remote methylene C−H (hetero)arylation of cycloalkane carboxylic acids, Science (2024). DOI: 10.1126/science.ado1246

Journal information: Science

Citation: Chemists develop new method for making gamma chiral centers on simple carboxylic acids (2024, May 17) retrieved 12 June 2024 from
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