Scripps Research chemist Matthew Disney, Ph.D., and colleagues have created drug-like compounds that, in human cell studies, bind and destroy the pandemic coronavirus' so-called "frameshifting element" to stop the virus from ...
Cell & Microbiology
Sep 30, 2020
0
209
The discovery of the molecule, an antibody known as CR6261, is good news for researchers who hope to design a flu vaccine that would give humans lifelong protection against a majority of influenza viruses. The antibody also ...
Biochemistry
Feb 26, 2009
0
0
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have improved a state-of-the-art gene-editing technology to advance the system's ability to target, cut and paste genes within human and animal cells—and ...
Biochemistry
Jun 19, 2017
0
44
Researchers at The Scripps Research Institute (TSRI) have designed a new molecule-building method that uses sulfones as partners for cross-coupling reactions, or the joining of two distinct chemical entities in a programmed ...
Materials Science
Mar 12, 2018
0
22
Scientists at Scripps Research have solved the structure of a key protein that senses when our cells swell. This protein, called SWELL1 (or LRRC8A), works as an "ion channel" on the cell membrane to relieve pressure inside ...
Biochemistry
Aug 16, 2018
0
113
Two chemists at The Scripps Research Institute have synthesized a new nano-scale scientific tool -- a tiny molecular switch that turns itself on or off as it detects metallic ions in its immediate surroundings.
Bio & Medicine
Apr 13, 2010
0
0
The 3-D structure of the virus, known as Seneca Valley Virus-001, reveals that it is unlike any other known member of the Picornaviridae viral family, and confirms its recent designation as a separate genus "Senecavirus." ...
Oct 8, 2008
2
0
A new chemistry method from scientists at Scripps Research in La Jolla, California, greatly simplifies the creation of an important class of compounds called hindered ethers, which are integral to many drugs and commercial ...
Materials Science
Sep 9, 2019
1
93
Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized 'miniecosystems' to quickly see if a molecule can function as a potential therapeutic.
Analytical Chemistry
Jun 18, 2018
0
101
Chemists at The Scripps Research Institute (TSRI) have invented a new technique for constructing one-handed or "chiral" drug molecules. The new method is already being adopted by pharmaceutical researchers.
Materials Science
Sep 1, 2016
0
6
