Facebook for the proteome

There are approximately 20,000 human genes that encode proteins, but despite remarkable progress since the human genome was first sequenced more than a decade ago, scientists still understand in detail how only a small fraction ...

How to kill a protein

For decades scientists have been looking closely at how our cells make proteins. But the inverse is equally important: how cells kill them.

How RNA machinery navigates our genomic obstacle course

Once upon a time, scientists thought RNA polymerase—the molecule that kicks off protein synthesis by transcribing DNA into RNA—worked like a wind-up toy: Set it down at a start site in our DNA and it would whir steadily ...

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