Scientists from the Friedrich group have developed a new virtual reality system that allows them to manipulate the sensory environment of adult zebrafish at will, while simultaneously analyzing neural activity. This approach ...
Plants & Animals
Mar 3, 2020
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52
The Gasser group discovered that silencing of heterochromatic regions—and more specifically of hundreds of Polycomb-target genes enriched for H3K27me3—can occur through selective RNA degradation, and not only through ...
Cell & Microbiology
Apr 24, 2020
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42
(Phys.org)—Scientists from the Friedrich Miescher Institute for Biomedical Research have elucidated the histone modifications that lead to the sequestration of silent genes at the nuclear periphery. In a study published ...
Cell & Microbiology
Aug 31, 2012
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All cells are confronted with DNA damage, for example by exposure of the skin to UV rays, chemical byproducts of nerve cells consuming sugar, or immune cells destroying bacteria. If these DNA lesions are not - or badly - ...
Cell & Microbiology
Jun 13, 2017
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183
Research groups led by Botond Roska at the Friedrich Miescher Institute for Biomedical Research (FMI) and Daniel Müller at the ETH Zurich Department of Biosystems Science and Engineering (D BSSE) have developed a novel method ...
Biotechnology
Dec 19, 2017
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36
FMI researchers have identified a synthetic protein that dampens the activity of a cellular pathway involved in viral infection. The findings could help to develop drugs that combat viruses such as influenza A and Zika.
Cell & Microbiology
May 11, 2022
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117
Proteins known as transcription factors act as switches that regulate the expression of nearby genes, but the identity of some of these genetic levers has so far remained mysterious. Now, researchers from the Schübeler group ...
Biotechnology
Jul 8, 2021
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30
UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by DNA repair machinery, acting as a molecular sunscreen. It has been unclear, however, how repair proteins work on DNA ...
Molecular & Computational biology
May 30, 2019
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82
Scientists at the Friedrich Miescher Institute for Biomedical Research have identified a novel and unexpected regulatory activity of RNA at the edge of inactive chromosomal regions. In their publication in Nature Structural ...
Cell & Microbiology
Aug 8, 2013
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0
Structural biologists at the Friedrich Miescher Institute for Biomedical Research have resolved the 3D structure of a protein machine that plays an important part in the maintenance of genomic stability. They have revealed ...
Cell & Microbiology
Feb 21, 2014
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