Genetic error led humans to evolve bigger, but more vulnerable, brains

August 21, 2018 by Anthony King, Horizon: The EU Research & Innovation Magazine
The skull of a Australopithecus sediba, a species of Australopithecines, who were our ancestors and whose brains started to grow two to three million years ago. Image credit - Credit: Australopithecus sediba by Brett Eloff, courtesy Profberger and Wits University is licensed under CC BY-SA 4.0

Newly-discovered genes that helped supersize human brains along with DNA retrieved from extinct humans, which can still be found in people living today, are expanding scientists' understanding of how our species evolved.

One of the major features that distinguish humans from other primates is the size of our brains, which underwent rapid evolution from about two to three million years ago in a group of our ancestors in Africa called the Australopithecines. During this period, the human brain grew almost three-fold to reach its current size. Scientists know this from skull remains, but have puzzled over how it happened.

This year, the mystery was partially solved by Professor Pierre Vanderhaeghenat the Flanders Institute for Biotechnology in Belgium. Prof. Vanderhaeghen, who was conducting his work as part of the GENDEVOCORTEX project, went on a hunt for the that drove the growth of human brains.

Scientists had suspected that brain expansion began in our human ancestors when they evolved genes that are switched on in the foetus, when a lot of key brain development occurs. Prof. Vanderhaeghen therefore looked for genes present in human foetal tissue, but missing from our closest living relatives, apes.

His lab discovered 35 hominid—present only in apes and humans—genesthat were active in foetal brain tissue. They then became intrigued by three specific genes—all similar to NOTCH genes, an ancient gene family involved in sending messages between cells and that are present in all animals. They found that the three new genes, collectively named NOTCH 2NL, were created by a copy and paste error of an original NOTCH gene.

This error created entirely new proteins which likely helped our ancestors' cerebral cortex to balloon. This is the part of our brain responsible for our language, imagination and problem-solving abilities. Scientists at the University of California, Santa Cruz, have also identified the NOTCH 2NL genes in DNA from Homo sapiens' extinct cousins—the Neanderthals and Denisovans.

'(The NOTCH 2NL) genes are only present in humans today. They were also present in Neanderthal DNA, but not in chimpanzees," Prof. Vanderhaeghen said.

Evolution

These genes control the growth rate and differentiation of brain stem cells—the starter cells that multiply and give rise to all neurons in our brain—causing them to seed more nerve cells, which in turn helped to expand brain size. The genes likely led to more neurons and brain tissue in our ancestor's descendants—including Neanderthals, Denisovans, and modern humans.

Prof. Vanderhaeghen's research could also help to provide new insights into brain disorders. The US researchers linked genetic faults in DNA that were very similar to NOTCH 2NL, to children born with enlarged brains or small brains. Many of the new human-specific genes are located in a small area of our genome that plays an important role in brain size, according to Prof. Vanderhaeghen.

As DNA in this area closely resembles another part of the genome where it was originally cut and pasted from millions of years ago, errors are more likely, said Prof. Vanderhaeghen. "Patients who have (inherited) deletions in this area tend to be at risk of developing schizophrenia, whereas patients with duplications are more at risk of autistic spectrum disorder," he said.

Prof. Vanderhaeghen is now studying some 20 of the remaining human-only genes to see how they contributed to the evolution of the human brain.

The use of genetics to study human evolution in this way is helping to transform our understanding of how our own species compared to our ancestors. Traditionally, scientists have studied extinct species by looking at the fossilised remains of their bones. This was how they discovered the existence of Neanderthals, the extinct human species that lived across Europe and much of Asia before vanishing around 40,000 years ago.

That many people still retain Neanderthal DNA today could mean that it plays a role in our immune system. Credit: Frank Vinken for Max Planck Society

In the last decade, however, scientists have begun to look at the DNA inside these bones. Professor Svante Pääbo, director of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, has led the way in sequencing DNA of these extinct humans from small bone fragments.

This allows scientists to compare modern human DNA with that of extinct humans, rather than just living relatives like chimps. Already, the work has revealed some surprising findings—our own species appears to have interbred with some of these ancient relatives during our history.

Ancient humans

Scientists have found that the DNA of every person outside Africa is 1–2% Neanderthal, meaning that these extinct human relatives had offspring with our own ancestors.

"Different people tend to carry different pieces of the Neanderthal genome," said Prof. Pääbo, who is undertaking a project called 100 Archaic Genomes to decipher the DNA of ancient human individuals.

"Something like 40–50% of the Neanderthal genome can still be found in people today," he said.

According to Prof. Pääbo, we retained some of this DNA because it offered an advantage to our ancestors. "Some (of this retained DNA) has to do with the immune system, presumably helping us to fight off infectious diseases."

The power of genetics to unravel the history of human evolution took a new twist in 2010 after Prof. Pääbo's lab sequenced DNA from a finger bone fragment found by a Russian archaeological team in a remote Siberian cave.

The analysis revealed the bone belonged to a previously unknown human relative, now called Denisovans after Denisova Cave where the bone was found. This mysterious ancient human species lived at around the same time as Neanderthals, but further east into Asia.

Last year, Prof. Pääbo's group published DNA sequences from a tooth found in the cave—the fourth ever Denisovan discovered. We now know Denisovan DNA carries more variation than Neanderthal DNA, leading scientists to conclude that they were more widespread than the better-known Neanderthals.

Denisovans left a more impressive stamp on some of us than Neanderthals, according to Prof Pääbo. Their DNA can be found in people across Asia today, while indigenous peoples of Papua New Guinea and Australia may carry up to 5%. Tibetans also carry some Denisovan DNA in their genomes, which has helped them adapt to life at high altitudes where there is little oxygen in the atmosphere.

Prof. Pääbo and his colleagues will soon publish their third high-quality genome—where almost the entire DNA sequence is intact—of a Neanderthal from Siberia. A deciphered genome of this quality allows for better DNA comparisons and could tell us more about the evolution of important genes—such as those linked to the development and function of the . It will add yet another puzzle piece to help us understand the history of our closest extinct relatives, according to Prof. Pääbo.

"There may even be other forms of extinct humans out there to be discovered by studying the DNA of the (ancient) bones we find," he said.

Explore further: Neanderthal genome shows early human interbreeding, inbreeding

More information: Ira Espuny-Camacho et al. Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain, Neuron (2017). DOI: 10.1016/j.neuron.2017.02.001

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Kyle423
2 / 5 (2) Aug 23, 2018
I have a feeling that Homo-Sapiens Killed off The Denisovans and the Neanderthals. Just look how Destructive we are, we dont get a long with strangers and are a conquering people. I dont believe for one second these other species just died off due to starvation or a cataclysm. For one there was no cataclysm 40,000 years ago. and they dont know when the Denisovans went extinct, and they were possibly thrown in a cave to die because of the sapiens. There have been other caves around the world that have piles of bodies in them, and I think Humans put them there after they slaughtered them. I guess my counter argument would be that, was there weapon damage to the bones? But what if they fought them with bare hands? who knows? But with countries having decade long wars with each other. I dont see why they didnt go to war with our cousins.
I also think in relation to this article, the rapid brain growth of our frontal cortex allowed us to become this destructive force of humans we are.
Nik_2213
5 / 5 (1) Aug 24, 2018
#K, that's a fair hypothesis. But, given small population sizes, it is more likely that subsequent folk simply out-competed earlier groups. And, there is genetic evidence of inter-marriage. Mate-choice is a potentially powerful selection effect...
DonGateley
not rated yet Sep 02, 2018
Did this copy and paste error happen with one individual who's offspring eventually dominated the entire species or are they claiming it occurred in parallel in many individuals? If the latter, why?

It also seems to imply that the brain enlargement occurred in a continuity of steps which seems to imply some kind of directed evolution. That is certainly outside the Darwinian paradigm of random changes.

OTOH, it is likely that Neanderthals, Denisovans and Sapiens were each concentrated in separate tribes with substantially different physiognomies. Since we have always practiced tribal warfare and still do today in some isolated cultures, the elimination of the first two groups by the third isn't particularly mysterious. Even in supposedly sophisticated cultures genocide is still being practiced.

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