Material enables more reliable and meaningful self-screening

February 25, 2016
A microscopic image of the newly-developed synthetic paper shows the ordered structure of the fibres. Credit: KTH Royal Institute of Technology

Paper-based diagnostics enable rapid medical test results at minimal cost—and now they're about to get even better. A new synthetic paper developed by Swedish researchers could enable simultaneous screenings for multiple conditions, with more reliable results.

Developed at Stockholm's KTH Royal Institute of Technology, the synthetic paper differs significantly from the most predominant paper diagnostics used today, such as pregnancy tests.

Jonas Hansson, researcher and PhD in the department Micro and Nanosystems at KTH, explains that the uniqueness can be found in the details. Unlike in standard paper-based diagnostic material, the structure of the synthetic paper is predetermined, not random, he says.

"Cellulose is the basis of the paper material used for absorbing blood samples or other body fluids. But the fibres in these papers are unstructured," Hansson says. "They occur helter-skelter in a random pattern with wide variation between one medical test and another."

In the synthetic paper developed by the researchers at KTH, fibres are arranged on the micrometer level. "We can define the exact distance between the fibres, their angle in relation to each other and their thickness," Hansson says. "All in a three-dimensional network."

This kind of precisions translates into more accurate and meaningful results. Hansson says that the synthetic paper can tell more than simply whether a person has a disease or not. It can enable a user to determine the concentration of one or more biomarkers in a body fluid.

"For some diseases, there are only small amounts of a biomarker available in the body, which means that the tests have to be very sensitive," Hansson says. "We also eliminate the variation between different sheets of paper because of differences in the structure, so all the medical tests will be as accurate."

Research colleague Wouter van der Wijngaart, professor of microsystems technology at the KTH, says that the new synthetic paper provides an optimal control of chemistry and fluid flow.

Some of the possibilities include combined pregnancy and HIV self-testing, with a single sample. "The surface of each fibre can be assigned chemical properties, such as how fast a liquid can be absorbed into the paper," van der Wijngaart says. "Different parts of the paper can be used for different types of tests."

While no specific diseases are singled out for application of the synthetic paper, the KTH researchers say screening is one future possibility, Hansson says.

"Someone who suspects they are having a heart attack can check themselves into an emergency room and get results within 20 to 30 minutes," Hansson says. "By contrast, the logistics of a hospital today mean test results are likely to take much longer than that. Heart attacks or various kidney diseases require very thorough testing tools, and the synthetic paper offers just that opportunity."

The synthetic paper could provide opportunities for health screening in places where medical and transportation infrastructure are lacking, such as sub-Saharan Africa. In other more developed parts of the world, self-testing can be expanded with better accuracy and ease of screening for many disease simultaneously.

"In the end it is the demand that drives this. A growing range of self-tests is becoming available in pharmacies. People can take charge of their own health as the health care system becomes more congested. In addition, people are more familiar with different diagnoses now, thanks to the web.

"Tests can be done anytime, anywhere without dedicated electronic equipment," he says. "They can be done be completely independently, or enlist the help of web apps for reading and interpretation. This is particularly relevant where more care is moving out of the clinic and into the home."

Explore further: Breakthrough for lab-on-a-chip material

Related Stories

Breakthrough for lab-on-a-chip material

February 24, 2016

Researchers at Sweden's KTH Royal Institute of Technology have developed a new polymer suited for photostructuring, which opens new possibilities for medical diagnostics, biophotonics and 3D printing.

Paper-based lateral flow assay for morphine

April 13, 2015

VTT is the first in the world to have developed a drug test printed on paper. VTT used antibodies – produced by methods of molecular biology – as morphine sensing molecules when creating this printing technology-based ...

Recommended for you

A new way to harness wasted methane

October 17, 2017

Methane gas, a vast natural resource, is often disposed of through burning, but new research by scientists at MIT could make it easier to capture this gas for use as fuel or a chemical feedstock.

Stiff fibres spun from slime

October 17, 2017

Nature is an excellent teacher – even for material scientists. Researchers, including scientists at the Max Planck Institute of Colloids and Interfaces, have now observed a remarkable mechanism by which polymer materials ...

Key to expanding genetic code described

October 17, 2017

Yale scientists have described the atomic structure of a protein that is the key tool in efforts by synthetic biologists to expand the genetic code.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.