The future of 'bioprocessing' for medical therapies

March 17, 2015, Wiley

What's in store for the future of industrial bioprocessing for medical therapies, which involves the use of living organisms or cells to create drugs or other agents? Will the batch or continuous bioprocessing platform dominate biomanufacturing of human therapeutics down the road? Three pioneers in the field address these questions in an upcoming issue of Biotechnology and Bioengineering.

With batch bioprocessing, components are transferred as a batch from one holding vessel or processing equipment to the next, while with continuous bioprocessing, there is a continuous flow like an assembly line. Dr. Matthew Croughan notes that we will never require a biopharmaceutical plant that truly needs to be continuous on a capacity basis. "We will never need to process 50,000 barrels—8 M liters—or more per day, like a continuous oil refinery," he said.

Dr. Konstantin Konstantinov and Dr. Charles Cooney stress that while we shouldn't close existing batch operations, methods are likely to evolve around continuous . Therefore, the development of this new platform should be given serious consideration.

Explore further: Henry Ford's ideas may cut the cost and speed production of medicines

More information: Croughan, M. S., Konstantinov, K. B. and Cooney, C. (2015), The future of industrial bioprocessing: Batch or continuous?. Biotechnol. Bioeng., 112: 648-651. DOI: 10.1002/bit.25529

Related Stories

Continuous drug manufacturing offers speed, lower costs

March 12, 2012

Traditional drug manufacturing is a time-consuming process. Active pharmaceutical ingredients are synthesized in a chemical manufacturing plant and then shipped to another site, where they are converted into giant batches ...

Recommended for you

A decade on, smartphone-like software finally heads to space

March 20, 2019

Once a traditional satellite is launched into space, its physical hardware and computer software stay mostly immutable for the rest of its existence as it orbits the Earth, even as the technology it serves on the ground continues ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.