Flexible LEDs for implanting under the skin

Flexible LEDs for implanting under the skin
Optical image of an 8x8μ-ILEDs array on a thin PDMS substrate in its on state under deformed conditions. Image credit: Nature Materials, doi:10.1038/nmat2879

(PhysOrg.com) -- Researchers in the US, China, Korea and Singapore have collaborated to develop flexible ultra-thin sheets of inorganic light emitting diodes (LEDs) and photodetectors for implantation under the skin for medical monitoring, activating photo-sensitive drugs, and other biomedical applications.

The research, led by John Rogers of the University of Illinois at Urbana-Champaign in the US, and published today in developed flexible arrays 2.5 μm thick and 100 x 100 μm square, which is much smaller than any commercially available array. They printed circuits directly onto a rigid glass substrate and then transferred them to an inexpensive biocompatible polymer called poly(dimethylsiloxane) (PDMS) to create a mesh-like array of LEDs and photodetectors.

The PDMS substrate is flexible enough that the circuits can still function even if twisted or stretched by even as much as 75 percent. Rogers said most research has concentrated on organic LEDs (OLEDs), which are extremely sensitive to water and oxygen, but the flexible arrays are encapsulated in a thin layer of silicon rubber, which makes them waterproof and allows them to function well when implanted or completely immersed in biofluids. The design also eliminates the mechanical constraints normally imposed on such devices by the inflexible semiconductor wafers that support them.

The researchers successfully tested the LEDs by integrating a sheet into the fingertip of a vinyl glove, which they then immersed in soapy water, and they have also implanted an array beneath the skin in an animal model.

Flexible LEDs for implanting under the skin
Schematic illustration of the encapsulation of an implantable array of μ-ILEDs. Image credit: Nature Materials, doi:10.1038/nmat2879

Potential biomedical applications for the include implantable patches for monitoring wound healing, for use in diagnosis or spectroscopy, or to control the delivery of drugs triggered by light in photodynamic drug therapy. They could also be used in light-emitting sutures or implantable illuminated plasmonic crystals, and may find application in robotics.

Rogers has recently founded a company in Cambridge, Massachusetts, mc10, to work on commercializing the new technology, which is a goal he regards as "incredibly appealing." Rogers said he wanted the technology to have an impact, and that was the end goal serving as the motivation for the work.

More information: Rak-Hwan Kim, et al., Waterproof AlInGaP optoelectronics on stretchable substrates with applications in biomedicine and robotics, Nature Materials, Advance online publication (2010) doi:10.1038/nmat2879

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