Phosphatidylinositol 3-kinase, or PI3K for short, is a family of lipid kinases that plays a key role in the human body, performing functions such as cell division, metabolism, and cell growth.
Molecular & Computational biology
Mar 7, 2022
0
40
In humans, virtually every cell stores fat. However, patients with a rare condition called congenital lipodystrophy, which is often diagnosed in childhood, cannot properly store fat, which accumulates in the body's organs ...
Cell & Microbiology
Feb 25, 2022
0
83
PSI scientists have shed light on an important component of the eye: a protein in the rod cells of the retina which helps us see in dim light. Acting as an ion channel in the cell membrane, the protein is responsible for ...
Molecular & Computational biology
Jan 3, 2022
0
363
Advanced molecular imaging technology has now mapped the structure of a drug widely used to treat fungal infections but whose workings have mystified researchers and physicians for nearly 70 years.
Molecular & Computational biology
Dec 9, 2021
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67
Using state-of-the-art technology and techniques, EMBL's Müller group has provided the most detailed structure to date of human RNA polymerase I (Pol I), offering fundamental information about cellular function for those ...
Molecular & Computational biology
Dec 9, 2021
0
22
It's an old needlework trick, and a protein in our body knows it: Instead of threading yarn into the eye from the end, it can be easier to pass a loop through it. This is how a protein in our body works, unfolding or separating ...
Molecular & Computational biology
Nov 29, 2021
0
32
For the first time, researchers have constructed a detailed 3D structure of human SAGA, a 20-piece molecular machine crucial to human life.
Molecular & Computational biology
Nov 23, 2021
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50
New research building on AI algorithms has enabled scientists to create more complete models of the protein structures in our bodies—paving the way for faster design of therapeutics and vaccines.
Molecular & Computational biology
Nov 2, 2021
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75
Double-stranded breaks (DSBs) are among the most hazardous forms of DNA damage. The checkpoint protein kinase ATM plays a key role in the repair of DSBs. Many anti-tumor drugs act by inducing DSB formation, so inhibition ...
Molecular & Computational biology
Sep 30, 2021
0
19
The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.
Molecular & Computational biology
Aug 13, 2021
0
289
