New prime editing system inserts entire genes in human cells

Researchers at the Broad Institute of MIT and Harvard have developed a new version of prime editing that can install or swap out gene-sized DNA sequences. First developed in 2019, prime editing is a precise method of making ...

Mapping enzyme catalysis with metabolic sensing

Enzymes maintain a range of protein sequences and diverse structural forms with activities that far exceed the best chemical catalysts. However, research on engineering them with new and improved features are limited due ...

New tool offers ways to improve CRISPR gene-editing method

The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently ...

Artificial intelligence helps to find new natural substances

More than a third of all medicines available today are based on active substances from nature, and a research team from the University of Jena has developed a procedure to identify small active substance molecules much more ...

The Spatial Mouse Atlas: New insights into cell fate

High-resolution gene expression maps have been combined with single-cell genomics data to create a new resource for studying how cells adopt different identities during mammalian development. The Spatial Mouse Atlas is the ...

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