Sample preparation is a fundamental laboratory technique encompassing all procedures required to convert a raw specimen into a form suitable for analytical measurement or experimental manipulation, while preserving analyte integrity and representativeness. It typically includes sampling, homogenization, separation, purification, concentration, and, when necessary, chemical derivatization. Methods vary by matrix and analytical modality (e.g., filtration, centrifugation, extraction, digestion, or fixation for microscopy), and are optimized to minimize contamination, losses, matrix effects, and chemical transformations. Rigorous sample preparation is critical for achieving accuracy, precision, sensitivity, and reproducibility in techniques such as chromatography, mass spectrometry, spectroscopy, and molecular biology assays.
EPFL scientists have developed a new research instrument for observing biological tissue samples prepared using a method discovered about forty years ago by Nobel Prize winner Jacques Dubochet, emeritus professor at the University ...
Bio & Medicine
Jun 7, 2023
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97
Ever since the discovery of the two-dimensional form of graphite (called graphene) almost twenty years ago, interest in 2D materials and their special physical properties has skyrocketed. Famously, graphene was produced by ...
Nanomaterials
Jun 1, 2023
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185
A research group led by Professor Minoru Osada (he, him) and postdoctoral researcher Yue Shi (she, her) at the Institute for Future Materials and Systems (IMaSS), Nagoya University in Japan, has developed a new technology ...
Nanomaterials
May 19, 2023
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352
Extracellular vesicles (EVs) are cell-secreted lipid bilayer bioparticles with a diameter of 30 to 250 nm. They are a promising source of biomarkers for liquid biopsies for early cancer diagnosis and real-time monitoring ...
Bio & Medicine
Apr 21, 2023
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178
A University of Minnesota Twin Cities-led team of scientists and engineers has developed a new method for making thin films of perovskite oxide semiconductors, a class of "smart" materials with unique properties that can ...
Nanophysics
Jan 3, 2023
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251
A research team from Skoltech, Aalto University, and Kurnakov Institute has recently developed a new, versatile and simple approach to using carbon nanotubes for manufacturing carbon nanotube-polymer nanocomposites. The method ...
Nanomaterials
Nov 25, 2022
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122
Nanomolding of topological nanowires could speed the discovery of new materials for applications such as quantum computing, microelectronics and clean-energy catalysts, according to an article co-authored by Judy Cha, professor ...
Nanophysics
Sep 12, 2022
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175
Two-dimensional transition metal chalcogenides (2D TMCs) have drawn great interest due to their abundant material choices and possible use in many areas like electronics and optoelectronics. As a complement to the widely-studied ...
Nanomaterials
Aug 29, 2022
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104
Researchers have published work in Advanced Materials describing a rapid and simple method to form ordered arrays of gold nanoparticles with plasmonic properties.
Nanomaterials
Aug 18, 2022
0
97
New research led by University of Massachusetts Amherst assistant professor Jinglei Ping has overcome a major challenge to isolating and detecting molecules at the same time and at the same location in a microdevice. The ...
Bio & Medicine
Jul 18, 2022
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276
