DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
An international team of researchers led by the Francis Crick Institute, the University of East Anglia and the Max Planck Institute for Evolutionary Anthropology has found that dogs were domesticated more than 14,000 years ...
Evolution
Mar 25, 2026
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Invasive species cost Canada billions of dollars each year. Now, a team led by UBC researchers has developed a new genomic test that can trace the Asian spongy moth—one of the biggest threats to North America's forests—back ...
Plants & Animals
Mar 24, 2026
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Researchers from the Earlham Institute, in collaboration with the Department of Biology at the University of Oxford, have discovered three previously unrecognized lineages of the protist Bodo, each with its own bacterial ...
Cell & Microbiology
Mar 23, 2026
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What can the world's longest living individual teach us about longevity? A team of scientists coordinated by the University of California, Davis, sequenced the Great Basin bristlecone pine genome, which could help unlock ...
Plants & Animals
Mar 23, 2026
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94
Studying endangered animal species without disturbing them and disrupting their natural habitat could be highly advantageous, as it would contribute to their protection and prevent unnecessary stress. Conventional methods ...
Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest questions. Consisting of amino acids strung together into peptide chains, these molecules perform much of ...
Biotechnology
Mar 18, 2026
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In a single experiment, scientists can decipher the entire genomes of many patient samples, animal models, or cultured cells. To fully realize the potential to study biology at this unprecedented scale, researchers must be ...
Biotechnology
Mar 17, 2026
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The genomes of phages—viruses that infect bacteria—are largely composed of "dark matter": genes that encode proteins whose functions remain unknown. Less than four years ago, a team led by Prof. Rotem Sorek at the Weizmann ...
Cell & Microbiology
Mar 16, 2026
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12
Researchers at Karolinska Institutet have developed a rapid and cost-efficient sequencing method that can identify antibiotic resistance within the same working day. The technique, called s5PSeq, measures how bacterial ribosomes ...
Cell & Microbiology
Mar 16, 2026
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10
A team of international scientists, including researchers at the Donald Danforth Plant Science Center, reports a major advance in sorghum genomics: a powerful new resource designed to speed discovery of traits that help crops ...
Molecular & Computational biology
Mar 12, 2026
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