DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
A new open-access study introduces RiSpy, a data-driven fingerprinting framework that makes the identification of genome-edited (GE) rice lines more robust, scalable and broadly applicable. Researchers from Sciensano, together ...
Biotechnology
Sep 17, 2026
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Structural variants and so-called tandem repeats are individual differences in the human genome. They are increasingly linked to diseases, but analyzing and interpreting them poses challenges for researchers.
Biotechnology
Sep 17, 2026
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145
Understanding gene regulation may be key to interpreting human disease genetics. Genes are regulated in part by stretches of DNA called enhancers, which define when, where and how strongly each gene is turned on. Mapping ...
Cell & Microbiology
Sep 17, 2026
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18
In a study published in the journal Nature Communications, researchers from the Royal Botanic Gardens, Kew, Forest Research and collaborating organizations present the first-ever European ash (Fraxinus excelsior) pangenome, ...
Ecology
Sep 17, 2026
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141
Scientists are getting a leg up on the rice stink bug, one of the most significant threats to rice, a staple food for nearly half the world's population and a major crop in Arkansas.
Molecular & Computational biology
Sep 17, 2026
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13
An international team that includes researchers from Murdoch University's Centre for Crop and Food Innovation (CCFI) has built the most comprehensive genetic map of the peanut yet and used this new genomic resource to breed ...
Molecular & Computational biology
Sep 15, 2026
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19
Monitoring marine life helps scientists track ecosystem health, improve conservation and manage fisheries. A promising approach is environmental DNA (eDNA), which refers to trace genetic material naturally released into the ...
Molecular & Computational biology
Sep 14, 2026
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12
A University of Newcastle-led global study has produced the most complete genetic picture yet of a salt-loving plant with the potential to help grow food in some of the world's harshest environments.
Molecular & Computational biology
Sep 14, 2026
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8
When public health researchers want to know whether diseases such as COVID-19 or polio are circulating in a community, they can look for genetic evidence in wastewater.
Ecology
Sep 14, 2026
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14
The globe is full of unknown species. But is it really possible to find a completely new animal species in the middle of the largest city in the United States?
Ecology
Sep 10, 2026
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21
