DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
Peanuts are an important staple crop for many people around the world. As well as being delicious as smooth or crunchy peanut butter, their seeds are high in healthy fats and protein and can be pressed into oil.
Molecular & Computational biology
Jun 17, 2026
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43
Genes aren't just transferred from parents to their offspring. Nature has found other ways to pass on genetic information, even between different species. And a new study, published in the journal Proceedings of the National ...
A new study led by Marco Fumasoni, principal investigator at Fundação GIMM, shows that evolution can substantially reduce cell size without significantly compromising cells' ability to grow. The work, carried out in yeast ...
Evolution
Jun 17, 2026
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24
An interdisciplinary team of Rice University researchers has uncovered previously unknown relationships between bacteriophages—viruses that infect bacteria—and their bacterial hosts, offering a powerful new tool for next-generation ...
Cell & Microbiology
Jun 16, 2026
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11
Genome sequencing has revealed insights into how current-day residents of the Faroe Islands can trace their ancestry to a North Atlantic founder population and how evolutionary forces have shaped their genomes since. The ...
Evolution
Jun 16, 2026
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80
In an advance that could one day lead to new treatments for neurodegenerative diseases, Meredith Jackrel, an associate professor of chemistry in Arts & Sciences at Washington University in St. Louis, and her team have developed ...
Biotechnology
Jun 13, 2026
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32
Researchers at the Center for Crop and Disease Management (CCDM) have developed a new system that combines spore trapping with advanced DNA sequencing to confirm fungicide resistance from air samples containing airborne spores.
Biotechnology
Jun 10, 2026
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6
The deep sea is a unique "evolutionary engine," with one of the richest and most unexplored sources of genetic diversity on Earth, according to a major new study that assessed its potential to transform biotechnology and ...
Evolution
Jun 10, 2026
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10
Sloths are the slowest mammals on the planet, but living in dense jungles has made them notoriously difficult to study. For the first time, scientists have now sequenced and analyzed the two-toed sloth genome and revealed ...
Evolution
Jun 9, 2026
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20
Ground squirrel droppings, preserved for millennia in the Yukon's deep permafrost, have yielded an enormous amount of environmental DNA from dozens of species of plants, insects, microbes and large mammals, offering detailed ...
Evolution
Jun 9, 2026
0
17
