DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
A bad apple doesn't always ruin the bunch. In fact, it might make the bunch a little stronger. A new study published in Horticulture Research by Ben Mansfeld, an assistant professor of biology in Arts & Sciences at Washington ...
Molecular & Computational biology
Sep 30, 2026
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14
Evolution is driven by changes in DNA that sometimes promote adaptation, altering traits like disease resistance or reproduction. Often, these changes are minuscule, modifying a single letter in the DNA code—somewhat like ...
Evolution
Sep 29, 2026
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68
In acute, life-threatening infections, rapidly characterizing the microorganisms in a patient sample can help guide diagnosis and treatment. Computational methods known as taxonomic profilers can analyze metagenome sequencing ...
Biotechnology
Sep 28, 2026
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41
For many years, antibiotics have been added to animal feed to help control harmful bacteria and improve growth. But amid concerns about antibiotic resistance—when bacteria adapt to survive treatments that would normally kill ...
Plants & Animals
Sep 25, 2026
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24
A new tool to mutate bacteriophages—viruses that infect bacteria—provides a "big leap" forward in our understanding of how they function and our ability to harness their full potential.
Cell & Microbiology
Sep 25, 2026
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153
Tiny insects called aphids inject hundreds of mysterious proteins into plants, hijacking the plants' own genomes to build galls: structures made of plant tissue but constructed to the insects' specifications to house and ...
Plants & Animals
Sep 24, 2026
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12
New research from the University of St Andrews has created the largest combined study of bat genomes and fossils ever undertaken, finding that bats most likely originated in Europe around 65 million years ago before spreading ...
Evolution
Sep 23, 2026
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89
Natural history collections around the world collectively hold more than 1 billion specimens, spanning a wide variety of times and places. These include species that are extinct or come from areas now transformed beyond recognition, ...
Plants & Animals
Sep 21, 2026
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21
A KAUST-led team has developed the AI tool Unify to help scientists compare similar cell types across distant species. This comparison can help researchers assess which findings from animal studies may be most relevant to ...
Evolution
Sep 21, 2026
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43
As we age, some of the cells in our body enter a state of senescence, in which they stop dividing but do not die. Those senescent cells can contribute to age-related disorders such as cancer, tissue degeneration and inflammatory ...
Cell & Microbiology
Sep 21, 2026
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