Research news on Biological networks

Biological networks, as physical systems, comprise interconnected biomolecular or cellular components whose interactions give rise to emergent functional organization in living organisms. They include gene regulatory, protein–protein interaction, metabolic, neuronal, and signaling networks, each instantiated by tangible entities such as DNA, proteins, metabolites, or cells and their spatially constrained contacts. These systems exhibit nontrivial topology (e.g., modularity, hubs, motifs) and dynamic behavior governed by biochemical reaction kinetics, diffusion, and mechanical coupling. Biological networks underpin robustness, adaptability, and information processing in cells and tissues, and are quantitatively studied using tools from statistical physics, nonlinear dynamics, and network theory.

Building a reference manual for how cells connect with each other

Every multicellular organism, from tiny worms to humans, elephants, and whales, needs a way for their cells to connect with each other to form tissues, organs, and organize their overall body plan. Cells have a variety of ...

Teaching machines to design molecular switches

In biology, many RNA molecules act as sophisticated microscopic machines. Among them, riboswitches function as tiny biological sensors, changing their 3D shape upon binding to a specific metabolite. This shape-change acts ...

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