Page 2: Research news on Biological networks

Biological networks, as physical systems, comprise interconnected biomolecular or cellular components whose interactions give rise to emergent functional organization in living organisms. They include gene regulatory, protein–protein interaction, metabolic, neuronal, and signaling networks, each instantiated by tangible entities such as DNA, proteins, metabolites, or cells and their spatially constrained contacts. These systems exhibit nontrivial topology (e.g., modularity, hubs, motifs) and dynamic behavior governed by biochemical reaction kinetics, diffusion, and mechanical coupling. Biological networks underpin robustness, adaptability, and information processing in cells and tissues, and are quantitatively studied using tools from statistical physics, nonlinear dynamics, and network theory.

Bacterial 'brains' operate on the brink of order and disorder

The sensory proteins that control the motion of bacteria constantly fluctuate. AMOLF researchers, together with international collaborators from ETH Zurich and University of Utah, found out that these proteins can jointly ...

How gut bacteria control immune responses

Bacteria in the human gut can directly deliver proteins into human cells, actively shaping immune responses. A consortium led by researchers at Helmholtz Munich, with participation from Ludwig Maximilians University (LMU), ...

Foundation model reveals how cells are organized in tissues

Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Nicheformer, the first large-scale foundation model that integrates single-cell analysis with spatial transcriptomics. Trained on ...

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