Bioinformatics is a computational and analytical technique that applies algorithms, statistical methods, and database technologies to the acquisition, storage, processing, and interpretation of biological data, particularly large-scale omics datasets such as genomes, transcriptomes, and proteomes. It encompasses sequence alignment, gene prediction, variant calling, structural modeling, functional annotation, and systems-level network analysis. Bioinformatics pipelines integrate heterogeneous data types, automate quality control, and support reproducible research through workflow management and version-controlled code. As a technique, it enables hypothesis generation, biomarker discovery, and rational design in fields including molecular biology, genomics, pharmacology, and systems biology by transforming raw high-throughput experimental outputs into interpretable, quantitative biological insight.
In the hunt for new therapeutics for cancer and infectious diseases, lasso peptides prove to be a catch. Their knot-like structures afford these molecules high stability and diverse biological activities, making them a promising ...
Biotechnology
Oct 16, 2025
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Every organism's genome contains mutations that often have unknown biological effects. In partnership with Stanford University, researchers at Charité—Universitätsmedizin Berlin have now discovered a way to predict the ...
Cell & Microbiology
Oct 10, 2025
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Researchers at University of Tsukuba have developed DeMemSeg, an AI-powered analysis pipeline that addresses a long-standing challenge in microscopy: precisely segmenting and measuring individual cell membranes that overlap ...
Cell & Microbiology
Oct 8, 2025
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By making the world's microbial DNA easier to explore, a new sequence alignment tool, LexicMap, lets scientists search for a DNA sequence against millions of bacterial and archaeal genomes in minutes, helping researchers ...
Biotechnology
Sep 30, 2025
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Population bottlenecks caused by stark population loss due to illness or habitat destruction caused mammals' disease immunity to decline, according to a new study led by computational biologists in the Penn State School of ...
Evolution
Sep 30, 2025
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Scientists from James Cook University have developed a new computer tool that reveals layers of gene activity that were previously invisible, opening fresh possibilities for understanding health and disease.
Biotechnology
Sep 25, 2025
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An international team of scientists, including from Rothamsted Research, have developed a new method to improve the accuracy of gene mapping in complex organisms—a breakthrough that could enhance research into fungal diseases ...
Molecular & Computational biology
Sep 23, 2025
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Analyzing single-cell RNA sequencing (scRNA-seq) data is crucial for understanding complex biological processes and disease development, but identifying individual cell types within these vast datasets has been a significant ...
Cell & Microbiology
Sep 11, 2025
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Artificial intelligence is now better than humans at identifying many patterns, but evolutionary relationships have always been difficult for the technology to decipher. A team from the Bioinformatics Department at Ruhr University ...
Evolution
Sep 10, 2025
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Researchers from the Belgian Federal Institute Sciensano, as part of the DARWIN project, have developed a proof-of-concept for next generation detection methods of genome-edited organisms.
Biotechnology
Sep 8, 2025
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