Bioinformatics is a computational and analytical technique that applies algorithms, statistical methods, and database technologies to the acquisition, storage, processing, and interpretation of biological data, particularly large-scale omics datasets such as genomes, transcriptomes, and proteomes. It encompasses sequence alignment, gene prediction, variant calling, structural modeling, functional annotation, and systems-level network analysis. Bioinformatics pipelines integrate heterogeneous data types, automate quality control, and support reproducible research through workflow management and version-controlled code. As a technique, it enables hypothesis generation, biomarker discovery, and rational design in fields including molecular biology, genomics, pharmacology, and systems biology by transforming raw high-throughput experimental outputs into interpretable, quantitative biological insight.
Biologists and computational scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory recently refined two artificial intelligence (AI) programs originally built by Meta, the company that owns Facebook, ...
Molecular & Computational biology
Sep 8, 2025
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In June, Google DeepMind took the wraps off AlphaGenome, its latest machine learning model for biological discovery. While DeepMind's Nobel Prize-winning AlphaFold model focuses on proteins and how they fold, AlphaGenome ...
Biotechnology
Sep 4, 2025
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Artificial intelligence relies on machine learning algorithms trained on massive datasets to make predictions—think of how ChatGPT learned language by gorging on the internet. In biology, however, scientists face a frustrating ...
Biotechnology
Sep 3, 2025
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Since its release in 2024, the open-source platform BindCraft, developed at EPFL, has already disrupted the world of protein design. Physical interactions between proteins influence anything from cell signaling and growth ...
Biotechnology
Aug 29, 2025
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When a tree dies, it forms the foundation for new life: In a slow, invisible process, leaves, wood and roots are gradually decomposed—not by wind or weather, but by millions and millions of tiny organisms.
Evolution
Aug 28, 2025
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New research from the Wisconsin Institute for Discovery is tackling a complex packing problem. Thanks to the development of a powerful new computational tool introduced in a study published in the journal Genome Research, ...
Biotechnology
Aug 28, 2025
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Tuberculosis (TB) is the world's deadliest infectious disease—and one of the hardest to cure. Standard treatment requires a cocktail of multiple drugs over at least six months, and one in five patients have a type of TB ...
Biotechnology
Aug 25, 2025
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Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing new therapeutic antibodies.
Biotechnology
Aug 19, 2025
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Proteins sustain life as we know it, serving many important structural and functional roles throughout the body. But these large molecules have cast a long shadow over a smaller subclass of proteins called microproteins.
Biotechnology
Jul 31, 2025
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102
Recent advances in computational protein design have depended mainly on neural networks and machine learning to generate binders. However, the complexity of protein–protein interactions and the limitations of data-driven ...
Biotechnology
Jul 30, 2025
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