MEG3 kissing loops essential for tumor suppression

A team of researchers in the Marcia group at EMBL Grenoble have discovered that the tumor suppressor MEG3 adopts a complex three-dimensional structure to fulfill its function. Furthermore, they were able to fine-tune its ...

Structure of fat-processing enzyme determined

After decades of work with no success, researchers have determined the high-resolution, three-dimensional structure for lipoprotein lipase, the enzyme that processes fats, or triglycerides, in the bloodstream and releases ...

New insights into magnetic quantum effects in solids

Using a new computational method, an international collaboration has succeeded for the first time in systematically investigating magnetic quantum effects in the well-known 3-D pyrochlore Heisenberg model. The surprising ...

The cryo-electron microscopy structure of huntingtin

Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. They lead to an incorrect form of the correspondent protein. With the help of cryo-electron microscopy researchers from the Max Planck ...

New interaction mechanism of proteins discovered

UZH researchers have discovered a previously unknown way in which proteins interact with one another and cells organize themselves. This new mechanism involves two fully unstructured proteins forming an ultra-high-affinity ...

Sticking sugar to protein

ETH researchers have succeeded in determining the 3-D structure of the enzyme that attaches sugar chains to proteins – a breakthrough that they recently published in the journal Science.

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