News tagged with tamoxifen
Clue to unusual drug-resistant breast cancers found
Researchers at the University of Illinois at Chicago College of Medicine have found how gene expression that may contribute to drug resistance is ramped up in unusual types of breast tumors. Their findings may offer new therapy ...
Oct 08, 2010 |
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Scientists discover five new genome regions that increase breast cancer risk
(PhysOrg.com) -- Scientists have found five new regions of the genome that increase a woman's risk of developing breast cancer by between 6 and 16 per cent, according to a study published in the journal 'Nature ...
May 11, 2010 |
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Landmark study confirms chemotherapy benefit in breast cancer patients
Chemotherapy generally improves survival in postmenopausal breast cancer patients, according to a landmark study led by Dr. Kathy Albain of Loyola University Health System.
Dec 11, 2009 |
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Researchers find possible clues to tamoxifen resistance in breast cancer patients
Breast cancer patients who become resistant to tamoxifen may have low levels of a protein called Rho GDI-alpha, according to a study published online March 30 in the Journal of the National Cancer Institute.
Mar 30, 2011 |
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Taking tamoxifen to prevent breast cancer can save lives and money
Tamoxifen, taken by certain women as a preventive measure against breast cancer, saves lives and reduces medical costs. That is the conclusion of a new study published early online in Cancer, a peer-reviewed journal of the ...
Mar 14, 2011 |
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Multiple childbirth linked to increased risk of rare, aggressive 'triple-negative' breast cancer
Full-term pregnancy has long been associated with a reduced risk of breast cancer, but a new study finds that the more times a woman gives birth, the higher her risk of "triple-negative" breast cancer, a relatively uncommon ...
Feb 24, 2011 |
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Getting more anti-cancer medicine into the blood
Scientists are reporting successful application of the technology used in home devices to clean jewelry, dentures, and other items to make anticancer drugs like tamoxifen and paclitaxel dissolve more easily in body fluids, ...
Jan 26, 2011 |
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Anti-estrogen medication reduces risk of dying from lung cancer
A new study has found that tamoxifen, an anti-estrogen breast cancer medication, may reduce an individual's risk of death from lung cancer. Published early online in Cancer, a peer-reviewed journal of the American Cancer ...
Jan 24, 2011 |
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Long-lasting benefit of radiotherapy for localized breast cancer confirmed in study
A study confirms the long-lasting benefit of radiotherapy for localized breast cancer, and reports importance of tamoxifen for reducing recurrence.
Dec 10, 2010 |
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Drugs before surgery help women avoid mastectomies
(AP) -- Taking hormone-blocking pills for a few months before breast cancer surgery can shrink tumors and allow many women to have just the lump removed instead of the whole breast, a new study suggests.
Sep 30, 2010 |
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Gene mutation increases thromboembolism risk in women taking tamoxifen
Women taking tamoxifen for early-stage breast cancer who developed blood clots were more likely to carry a gene mutation for clotting than women taking tamoxifen who did not develop blood clots, according to an online study ...
Jun 16, 2010 |
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Cell study finds receptor can fight tamoxifen-resistant breast cancer cells
A receptor that is present in the nucleus of cells can, when activated, slow the growth of tamoxifen-resistant breast cancer cells, a new study found. The study built on the recent discovery that farnesoid X receptor (FXR) ...
Apr 27, 2010 |
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Study: 2 good choices to prevent breast cancer
(AP) -- Older women at higher risk for breast cancer now have two good drug options for preventing the disease, but they will have to weigh the trade-offs, a major study shows.
Apr 19, 2010 |
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How breast cancer cells evade therapeutic attacks
Tumour cells depend upon estrogens to survive and proliferate in about 70% of all breast cancer cases. The most frequently used treatment to fight this variety of tumours relies on anti-estrogens such as tamoxifen. However, ...
Mar 31, 2010 |
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Researchers say flower power may reduce resistance to breast cancer drug tamoxifen
Combining tamoxifen, the world's most prescribed breast cancer agent, with a compound found in the flowering plant feverfew may prevent initial or future resistance to the drug, say researchers at Georgetown Lombardi Comprehensive ...
Feb 16, 2010 |
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Tamoxifen
Tamoxifen is an antagonist of the estrogen receptor in breast tissue and is therefore used in the treatment of breast cancer. As of 2004, it was the world's largest selling drug for that purpose.
Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
Tamoxifen was discovered by ICI Pharmaceuticals (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."
For more information about Tamoxifen, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
