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News tagged with splicing

Researchers crack 'splicing code,' solve a mystery underlying biological complexity

Researchers at the University of Toronto have discovered a fundamentally new view of how living cells use a limited number of genes to generate enormously complex organs such as the brain.

Medicine & Health / Genetics

created May 05, 2010 | popularity 4.8 / 5 (18) | comments 50 | with audio podcast

Engineered molecule changes itself to detect and attack diseased cells

(PhysOrg.com) -- Assistant Professor of Bioengineering Christina Smolke has engineered biological molecules that regulate a cell's behavior by adjusting their own forms and functions in response to the internal conditions ...

Biology / Biotechnology

created Nov 30, 2010 | popularity 5 / 5 (4) | comments 1 | with audio podcast

Research uncovers new exception to decades-old rule about RNA splicing

There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a Cold Spring Harbor Laboratory (CSHL) study on RNA splicing, a cellular editing process. The rule-flaunting ...

Biology / Biotechnology

created May 17, 2012 | popularity 5 / 5 (4) | comments 0 | with audio podcast

Researchers discover a switch that controls stem cell pluripotency

Scientists have found a control switch that regulates stem cell "pluripotency," the capacity of stem cells to develop into any type of cell in the human body. The discovery reveals that pluripotency is regulated by a single ...

Biology / Cell & Microbiology

created Sep 15, 2011 | popularity 4 / 5 (4) | comments 0 | with audio podcast

Scientists clarify editing error underlying genetic neurodegenerative disease

Two molecular biologists at Cold Spring Harbor Laboratory have uncovered important new details about how a gene mutation causes a cellular editing error that results in a devastating disease called pontocerebellar hypoplasia ...

Biology /

created Jan 28, 2009 | popularity 5 / 5 (3) | comments 0

Scientists discover master regulator of motor neuron firing

(PhysOrg.com) -- When the Human Genome Project was complete, DNA bowed out of the limelight and gave way to RNA as a major player in genetic regulation. Now, findings at Rockefeller University mirror this ...

Medicine & Health / Neuroscience

created Mar 16, 2009 | popularity 4.7 / 5 (3) | comments 0

Researchers find mechanism underlying alt. splicing of premessenger RNA into messenger RNA

An international research team led by Tim Nilsen, Ph.D., a professor of medicine and biochemistry and the director of the School of Medicine's Center for RNA Molecular Biology, has discovered an unexpected mechanism governing ...

Biology /

created Dec 24, 2008 | popularity 5 / 5 (2) | comments 1

Cancer-associated long non-coding RNA regulates pre-mRNA splicing

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production. Their study appears in the ...

Biology / Cell & Microbiology

created Sep 23, 2010 | popularity 5 / 5 (1) | comments 0

Of yeast and men: Unraveling the molecular mechanisms of Friedreich's ataxia

Researchers in human genetics have long known that expansions of GAA repeats - resulting in this nucleotide triplet repeating hundreds or thousands of times - cause the most common hereditary neurological disorder known as ...

Biology / Cell & Microbiology

created Jul 09, 2009 | popularity 4 / 5 (1) | comments 0