Chromatin regulation enables generation of diverse antibodies

We need a variety of antibody types to help fight off invading foreign pathogens and our genome is exquisitely tuned to produce them to meet emerging needs. A new study finds that not just our DNA, but its configuration and ...

How organ functions were shaped over the course of evolution

A large-scale study conducted by molecular biologists from Heidelberg University has yielded groundbreaking new insights into the evolution and regulation of gene expression in mammalian organs. The scientists investigated ...

The search for molecular glue in targeted disease control

In cells, there are proteins that do the work and proteins that regulate them. The latter inhibit or enhance activity, depending on the need. However, in many diseases—for example cancer—there is so much overactivity ...

Epigenetics and cell diversity in the embryo

A research team at the Max Planck Institute for Molecular Genetics in Berlin has explored the role of factors in embryonic development that do not alter the sequence of DNA, but only epigenetically modify its "packaging". ...

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