Proteins are important building blocks in our cells and each cell contains millions of different protein molecules. They are involved in everything from structural to regulatory aspects in the cell. Proteins are constructed ...
Cell & Microbiology
Sep 18, 2014
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Living cells are like miniature factories, responsible for the production of more than 25,000 different proteins with very specific 3-D shapes. And just as an overwhelmed assembly line can begin making mistakes, a stressed ...
Cell & Microbiology
Sep 11, 2014
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Scientists at The Scripps Research Institute (TSRI) have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest ...
Cell & Microbiology
Mar 4, 2014
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Research by the University of Southampton has provided new insight into the consequence of accumulated 'misfolded proteins' in neurodegenerative disorders, such as Prion and Alzheimer's disease.
Biochemistry
Feb 14, 2014
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At the heart of brain diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's disease is protein misfolding, in which distorted proteins are unable to perform their normal functions. At ...
Cell & Microbiology
Jan 16, 2014
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Northwestern University scientists are the first to discover a cellular process used by animals when a tissue is stressed and in molecular trouble from the expression of misfolded and damaged proteins: The tissue at risk ...
Cell & Microbiology
Jun 7, 2013
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An effort to develop software that unravels the complexities of how proteins fold is paying dividends in new findings on how they misfold, according to researchers at Rice University.
Biochemistry
Jan 14, 2013
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(Phys.org) -- Researchers at the University of Alberta's physics department and the National Institute for Nanotechnology (NINT) are the first to map out the folding pathways of prions, malformed proteins that ...
Biochemistry
May 30, 2012
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(Phys.org) -- University of Delaware assistant professor David W. Colby is co-author of a paper in the March 23 issue of the Journal of Biological Chemistry that suggests protein misfolding may occur early in the pathogenesis, ...
Biochemistry
Apr 6, 2012
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Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic ...
Biotechnology
Jan 6, 2012
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