In a study with implications for chronic infections, Princeton researchers have described multiple pathways that some bacteria use to tolerate normally lethal antibiotic treatments. The findings overturn common assumptions ...
Cell & Microbiology
Apr 20, 2021
0
89
Scientists at Tokyo Institute of Technology (Tokyo Tech) have uncovered mechanisms underlying the activation of the MRN complex—the cell's DNA scissors. Using purified yeast proteins, they demonstrated that phosphorylation ...
Biotechnology
Mar 10, 2021
0
12
DNA damage can occur anywhere in the genome, but most DNA is wrapped around nucleosomes making it inaccessible to the repair machinery. Researchers from the Gasser group now show that DNA damage induces histone depletion, ...
Molecular & Computational biology
Sep 24, 2020
0
31
Reconstitution of the activation of the MLH1–MLH3 endonuclease shows how crossovers are formed during meiosis.
Molecular & Computational biology
Aug 20, 2020
0
2
Homologous recombination is an essential process of DNA repair to maintain genomic integrity of the organism. Now, researchers from Japan have identified mechanisms that choose between alternate pathways of DNA repair to ...
Evolution
Apr 30, 2020
0
17
How do you make yeast work harder? Not to make bread, but in processes that yield chemicals and pharmaceuticals. Industries currently use a yeast called Saccharomyces cerevisiae. They'd like it to work better. The answer ...
Biotechnology
Jan 14, 2019
0
21
One of the worst things that can happen to a cell is to end up with the wrong number of chromosomes. This can happen if something goes wrong during cell division, and it can lead to infertility, miscarriages, birth defects, ...
Cell & Microbiology
Oct 4, 2018
0
55
Researchers from the Department of Cell Biology, Physiology and Immunology and the Institute for Biotechnology and Biomedicine of the Universitat Autònoma de Barcelona (IBB-UAB) have unmasked the function of a protein involved ...
Cell & Microbiology
Jul 9, 2018
0
11
Researchers from several Russian institutes, including MIPT, have found out how prolonged exposure to ionizing radiation affects human stem cells. They discovered that it causes a cell cycle delay, which leads to faster repairs ...
Cell & Microbiology
Aug 25, 2017
0
6
A team of researchers from the biology department at TU Darmstadt has discovered that the processes for repairing DNA damage are far more complex than previously assumed. The ends of breaks in the double helix are not just ...
Cell & Microbiology
Feb 2, 2017
0
9
