After 20 years of dedicated research, scientists have cracked the chemical code of an incredibly complex 'anti-tumour antibiotic' known to be highly effective against cancer cells as well as drug-resistant bacteria, and have ...
Biochemistry
Apr 24, 2019
0
258
The development and improvement of pharmaceuticals plays the central role in the ongoing battle against human disease. Organic synthesis is the field that enables these developments as it offers the toolbox to diversify chemical ...
Biochemistry
Mar 5, 2019
0
24
With its vast numbers of different lifeforms, the sea is a largely unexplored source of natural products that could be starting points for new pharmaceuticals, such as the antitumor drugs trabectedin and lurbinectedin. Because ...
Materials Science
Feb 19, 2019
0
40
The preparation of chiral compounds as intermediates in drug synthesis is one of the most important targets in synthetic organic chemistry. Japanese scientists have now shown that the autocatalytic preparation of a chiral ...
Materials Science
Oct 19, 2016
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8
The lab of Rice University synthetic organic chemist K.C. Nicolaou has reported the streamlined total synthesis of delta12-prostaglandin J3, a molecule previously claimed to kill leukemic cancer cells.
Biochemistry
May 23, 2016
0
36
A team led by Rice University synthetic organic chemist K.C. Nicolaou has developed a new process for the synthesis of a series of potent anti-cancer agents originally found in bacteria.
Biochemistry
Mar 10, 2016
1
82
Viruses can be elusive quarry. RNA viruses are particularly adept at defeating antiviral drugs because they are so inaccurate in making copies of themselves. With at least one error in every genome they copy, viral genomes ...
Cell & Microbiology
Nov 20, 2012
2
0
Transcription is a cellular process by which genetic information from DNA is copied to messenger RNA for protein production. But anticancer drugs and environmental chemicals can sometimes interrupt this flow of genetic information ...
Biochemistry
Aug 21, 2012
0
0
(PhysOrg.com) -- New active substances can be produced quickly and efficiently with the help of reaction cascades. Once set in motion, these processes lead to the desired end product via a series of intermediate steps which ...
Biochemistry
Dec 26, 2011
0
0
(PhysOrg.com) -- Research provides insight into novel approach which could be used in pharmaceutical drug synthesis.
Materials Science
Oct 26, 2011
0
0
