The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism that allows chromosomal ...
May 23, 2013
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(Phys.org) —Newcastle University scientists have revealed the mechanism that causes a slime to form, making bacteria hard to shift and resistant to antibiotics.
Apr 12, 2013
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(Phys.org) —Scientists at the U.S. Department of Energy's Argonne National Laboratory, in collaboration with researchers from the Sanford-Burnham Medical Research Institute in Orlando, Fla., recently determined ...
Apr 05, 2013
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Berkeley Lab and UC Berkeley researchers have discovered that the transcription factor protein TFIID coexists in two distinct structural states, a key to genetic expression and TFIID's ability to initiate ...
Jan 17, 2013
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Fifty years ago, British researcher John Gurdon demonstrated that genetic material from non-reproductive, or somatic, cells could be reprogrammed into an embryonic state when transferred into an egg. In 2006, ...
Nov 15, 2012
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A group of researchers at the University of California, Berkeley have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs.
Nov 15, 2012
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The Biofactory, a leading innovator in incubating biomedical and life sciences related technologies, introduced today its ColoQuik line of label-free kits for the rapid colorimetric detection of protein-DNA interactions in ...
Nov 14, 2012
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In silico prediction of protein folding has the potential to reveal the specificity of a given protein sequence for DNA. Such methods are particularly promising as they could open the road to the rational ...
Oct 15, 2012
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(Phys.org)—The sorcerer's apprentice started a water-carrying system, but couldn't stop it, and soon he was up to his neck in water, and trouble. Living cells have a better design: When they activate a ...
Sep 06, 2012
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Next week's Journal of Biological Chemistry "Paper of the Week" by Wai Mun Huang and colleagues at the University of Utah Health Sciences Center and the University of Minnesota reveals new insights into the molecular proper ...
Jul 11, 2012
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(PhysOrg.com) -- A better understanding of gene function in model plant and animal systems could be used to develop useful traits in livestock and crop plants, and might someday lead to developments in stem ...
Feb 13, 2012
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Double-stranded DNA must disentangle itself into single strands during replication or repair to allow functional molecules to bind and perform their various operations. Cellular proteins specifically bind ...
Nov 29, 2011
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A recent study carried out at the State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China-Research, and published in the May 2011 issue of Science China Life Sciences (Issue 54) de ...
May 20, 2011
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For several decades, researchers have been linking genetic mutations to diseases ranging from cancer to developmental abnormalities. What hasn't been clear, however, is how the body's genome sustains such destructive glitches ...
Feb 02, 2011
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Researchers report that a single-stranded DNA-binding protein (SSB), once thought to be a static player among the many molecules that interact with DNA, actually moves back and forth along single-stranded ...
Oct 21, 2009
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