Uncovering a reversible master switch for development

In a paper published in Genes & Development, BWH principal investigator Mitzi Kuroda, PhD, and her team identified a reversible "master switch" on most developmental genes. The team unearthed this biological insight through ...

Single-molecule dissection of developmental gene control

Scientists at EPFL and Max Plank have made significant discoveries on how developmental genes are controlled by the methyltransferase enzyme PRC2. The study is published in Nature Structural & Molecular Biology.

A guardian gene for female sex

Researchers at INRA, France, have just uncovered one of the major genes responsible for female differentiation: FOXL2. During normal development, the formation of testes or ovaries in a foetus depends on the presence or absence ...

The developmental on-switch

German researchers have demonstrated for the first time why the molecular cocktail responsible for generating stem cells works. Sox2 and Oct4 are proteins whose effect on cells resembles that of an eraser: They remove all ...

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