Why is the immune system able to fight off some viruses but not others, leading to chronic, life-threatening infections like HIV and hepatitis C?
Cell & Microbiology
May 8, 2009
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For the first time, a team of researchers at the University of Pennsylvania School of Veterinary Medicine have imaged in real time the body's immune response to a parasitic infection in the brain.
Jan 28, 2009
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Virtual memory CD8+ T cells (TVM) are a relatively recent discovery in humans. A new review discusses what is known about them from mouse models and their cellular equivalents in humans, as described in the Journal of Interferon ...
Cell & Microbiology
Sep 28, 2022
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A cytotoxic T cell (also known as TC, CTL, T-Killer cell, cytolytic T cell, CD8+ T-cells or killer T cell) belongs to a sub-group of T lymphocytes (a type of white blood cell) that are capable of inducing the death of infected somatic or tumor cells; they kill cells that are infected with viruses (or other pathogens), or are otherwise damaged or dysfunctional. Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigenic peptide bound to Class I MHC molecules, present on all nucleated cells, and a glycoprotein called CD8, which is attracted to non-variable portions of the Class I MHC molecule. The affinity between CD8 and the MHC molecule keeps the TC cell and the target cell bound closely together during antigen-specific activation. CD8+ T cells are recognized as TC cells once they become activated and are generally classified as having a pre-defined cytotoxic role within the immune system.
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