Search results for chromosome inactivation

Cell & Microbiology Sep 3, 2025

'Mob breaker' TRIM37 prevents abnormal cell division by eliminating extra spindle poles

In 2000, researchers discovered that mutations that inactivate a gene known as TRIM37 cause a developmental disease called Mulibrey nanism. The extremely rare inherited disorder leads to growth delays and abnormalities in ...

Biotechnology Jul 15, 2025

Scientists develop technique for high-resolution single cell epigenetic analysis

Van Andel Institute scientists have developed an improved technique to comprehensively profile DNA methylation in single cells, an advance that will help researchers better study the role of epigenetics in cancer and other ...

Molecular & Computational biology May 15, 2025

Scientists track down mutation that makes orange cats orange

Scientists have confirmed that there is something unique about ginger-hued domestic felines. In a new study, Stanford Medicine researchers have discovered the long-posited but elusive genetic mutation that makes orange cats ...

Plants & Animals May 15, 2025

Orange cats come with genetic twist: X-linked mutation points to new mechanism for coloring

From Tama, Japan's most famous stationmaster calico cat, to the lasagna-loving, ginger Garfield, cats with orange fur are both cultural icons and beloved pets. But their distinctive color comes with a genetic twist—most orange ...

Biotechnology Apr 10, 2025

Simple, cost-effective reporter assay can evaluate chemical-induced epigenetic changes

Chemicals used as food preservatives, flavoring agents, dyes, pesticides, cosmetics, cleaners, and other industrial materials are being increasingly recognized as a health hazard. Their rampant use has led to an increase ...

Cell & Microbiology Jan 20, 2025

RNA's biophysical behavior offers new insights into X chromosome inactivation

Science has revealed some of the secrets of the X chromosome, but many remain. In humans, female cells contain two X chromosomes (XX) and male cells contain one (XY). In each female cell, one X chromosome must be inactivated—crumpled ...

Cell & Microbiology Jan 13, 2025

Embryo development hinges on sugar-modified proteins, study demonstrates

Protein modifications are key to cell survival because they ensure they do what they are supposed to do in a healthy system. One vital modification involves adding sugar molecules to proteins, a process known as glycosylation. ...

Plants & Animals Dec 7, 2024

Geneticists have finally solved the mystery of Garfield's orange coat

Garfield, star of the eponymous comic strip created by Jim Davis in 1978, is, like many of the cats that roam our homes, orange. He is orange in the same way that some people are redheaded, some horses are brown, or some ...

Cell & Microbiology Aug 30, 2024

Scientists discover molecular mechanism that plays key role in gene transcription and macrophage functional activation

As the largest variant of the histone H2A family, macroH2A plays significant regulatory roles in various processes such as X-chromosome inactivation, embryonic development, cellular metabolism, and tumorigenesis due to its ...

Molecular & Computational biology Feb 3, 2024

Lupus and other autoimmune diseases strike far more women than men. Now there's a clue why

Women are far more likely than men to get autoimmune diseases, when an out-of-whack immune system attacks their own bodies—and new research may finally explain why.

page 1 from 16