The Broad Institute is a genomic medicine research center located in Cambridge, Massachusetts, United States. Although it is independently governed and supported as a 501(c)(3) nonprofit research organization, the institute is formally affiliated with the Massachusetts Institute of Technology, Harvard University and its affiliated hospitals. The faculty and staff of the Broad Institute include physicians, geneticists, and molecular, chemical, and computational biologists.
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A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes—organisms that ...
Biotechnology
Jun 28, 2023
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Over the past 100 million years, mammals have adapted to nearly every environment on Earth. Scientists with the Zoonomia Project have been cataloging the diversity in mammalian genomes by comparing DNA sequences from 240 ...
Evolution
Apr 27, 2023
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581
Cyclosporine is one of the most common and effective immunosuppressant drugs used to treat chronic diseases like arthritis and psoriasis, but it comes with a risk of serious side effects. Scientists think that may be because ...
Biochemistry
Sep 27, 2022
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84
Genetic studies have revealed many genes linked to both common and rare disease, but to understand how those genes bring about disease and use those insights to help develop therapies, scientists need to know where they are ...
Cell & Microbiology
May 12, 2022
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121
Researchers at the Broad Institute of MIT and Harvard have developed a new version of prime editing that can install or swap out gene-sized DNA sequences. First developed in 2019, prime editing is a precise method of making ...
Cell & Microbiology
Dec 10, 2021
2
1310
Within the last decade, scientists have adapted CRISPR systems from microbes into gene editing technology, a precise and programmable system for modifying DNA. Now, scientists at MIT's McGovern Institute and the Broad Institute ...
Molecular & Computational biology
Sep 10, 2021
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244
An international team of researchers with an effort called the Zoonomia Project has analyzed and compared the whole genomes of more than 80 percent of all mammalian families, spanning almost 110 million years of evolution. ...
Ecology
Nov 11, 2020
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425
A team from the Broad Institute of MIT and Harvard has developed a new CRISPR genome-editing approach by combining two of the most important proteins in molecular biology—CRISPR-Cas9 and a reverse transcriptase—into a ...
Biotechnology
Oct 21, 2019
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339
Many of the world's most common or deadly human pathogens are RNA-based viruses—Ebola, Zika and flu, for example—and most have no FDA-approved treatments. A team led by researchers at the Broad Institute of MIT and Harvard ...
Cell & Microbiology
Oct 10, 2019
3
3219
A new technique developed by scientists at the Broad Institute of MIT and Harvard gives an unprecedented view of the cellular organization of tissues. Known as Slide-seq, the method uses genetic sequencing to draw detailed, ...
Cell & Microbiology
Mar 28, 2019
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134
