Nanoparticles may cause arterial disease

May 01, 2007

A U.S. study has found nanosized particles near plaque-filled arteries in animals that might contribute to arterial calcification.

The research, led by Maria Kraemer, a Mayo Clinic Graduate School student, suggests nanoparticles might represent a previously unrecognized factor in the development of arteriosclerosis and calcific arterial disease.

Kraemer and colleagues reported isolating and propagating self-replicating, self-calcifying, nanoparticles from human arteriosclerotic aneurysms and kidney stones.

"The work we are doing with human-derived nanoparticles is important because preliminary studies indicate they may increase negative responses to arterial injury, possibly leading to blocked arteries and arterial calcification," Kraemer said.

Researchers tested their hypothesis by inoculating animal models with nanoparticles from human calcified tissues. A second group of models received a diluted inoculation. Blocked arteries were apparent in some animals in both groups 35 days after receiving the dosage.

The study was presented Sunday in Washington during the Experimental Biology 2007 meeting.

Copyright 2007 by United Press International

Explore further: Nano-scale gold particles are good candidates for drug delivery

add to favorites email to friend print save as pdf

Related Stories

Google made failed bid for Spotify

3 hours ago

Internet titan Google tried last year to buy streaming music service Spotify but backed off for reasons including a whopping price tag, the Wall Street Journal reported on Tuesday.

Thieves got into 1K StubHub accounts

3 hours ago

(AP)—Cyber thieves got into more than 1,000 StubHub customers' accounts and fraudulently bought tickets for events through the online ticket reseller, a law enforcement official and the company said Tuesday.

Microsoft CEO sees 'bold' plan as 4Q tops Street

3 hours ago

(AP)—Microsoft Corp. CEO Satya Nadella painted an upbeat vision of the future Tuesday, saying that the next version of Windows will be unified across screens of all sizes and that two money-losing units—Nokia ...

Recommended for you

Graphene surfaces on photonic racetracks

9 hours ago

In an article published in Optics Express, scientists from The University of Manchester describe how graphene can be wrapped around a silicon wire, or waveguide, and modify the transmission of light through it.

Simulating the invisible

10 hours ago

Panagiotis Grammatikopoulos in the OIST Nanoparticles by Design Unit simulates the interactions of particles that are too small to see, and too complicated to visualize. In order to study the particles' behavior, he uses ...

Building 'invisible' materials with light

11 hours ago

A new method of building materials using light, developed by researchers at the University of Cambridge, could one day enable technologies that are often considered the realm of science fiction, such as invisibility ...

User comments : 0