New approach to treating breast and prostate cancers

Feb 09, 2010

In a new approach to developing treatments for breast cancer, prostate cancer and enlarged hearts, Loyola University Chicago Stritch School of Medicine researchers are zeroing in on a workhorse protein called RSK.

When activated, RSK is involved in cell survival, and cell enlargement. These properties contribute towards cancer progression, heart enlargement and tumors associated with a genetic disease called Carney complex. Loyola researchers have discovered that a binds to RSK. This regulatory protein effectively keeps RSK's activity in check.

In a study to be published in the , Patel and colleagues located the specific region of the regulatory protein that binds to RSK. The study was published online Jan. 4 in advance of print publication.

"The implications are widespread, and will also change textbooks for students," said Tarun Patel, PhD, chairman of the Department of Molecular Pharmacology & Therapeutics at Loyola University Chicago Stritch School of Medicine.

It was previously known that the regulatory protein that binds RSK is also associated with another enzyme known as PKA. PKA is critical in maintaining normal body functions including heart rate, contraction of the heart, blood pressure, hormone release, learning and memory. PKA also is involved in modulating tumor growth and progression. Because RSK and PKA compete for binding with the same regulatory protein, they end up modulating each other's activities.

These fundamental findings could point toward new approaches to developing drugs to keep RSK or PKA in check. Such drugs would, in effect, do the job of the regulatory protein. This could prove useful in treating conditions in which RSK is activated, such as breast and and heart enlargement.

Patel said this discovery is also of great importance for patients with Carney complex. Carney complex is an inherited disease that includes such symptoms as spotty skin pigmentation, benign or cancerous tumors of hormone-producing glands, and unusual benign tumors in the heart that can cause fatal heart attacks. Approximately 500 cases have been reported in the United States.

It's been known for years that Carney complex is associated with mutations that cause a deficiency of the regulatory protein that the Patel lab discovered binds to RSK. This would lead to activation of RSK in Carney complex patients and contribute to tumor growth. Currently there are no drugs to specifically treat Carney complex. Therefore, developing medications to inactivate RSK could prove to be an important new therapeutic approach for Carney complex patients.

Explore further: Breakthrough points to new drugs from nature

Provided by Loyola University

3.5 /5 (4 votes)
add to favorites email to friend print save as pdf

Related Stories

The beat goes on with AKAP18

Sep 28, 2007

A protein, known as AKAP18, could help the heart to beat faster in response to adrenaline or noradrenaline, according to a study published online this week in EMBO reports.

Study reveals the regulatory mechanism of key enzyme

Sep 20, 2007

Research conducted at the University of California, San Diego (UCSD) School of Medicine has shed new light on the structure and function of one of the key proteins in all mammalian cells, protein kinase A ...

Recommended for you

Breakthrough points to new drugs from nature

20 hours ago

Researchers at Griffith University's Eskitis Institute have developed a new technique for discovering natural compounds which could form the basis of novel therapeutic drugs.

World's first successful visualisation of key coenzyme

20 hours ago

Japanese researchers have successfully developed the world's first imaging method for visualising the behaviour of nicotine-adenine dinucleotide derivative (NAD(P)H), a key coenzyme, inside cells. This feat ...

User comments : 0

More news stories

Breakthrough points to new drugs from nature

Researchers at Griffith University's Eskitis Institute have developed a new technique for discovering natural compounds which could form the basis of novel therapeutic drugs.

A greener source of polyester—cork trees

On the scale of earth-friendly materials, you'd be hard pressed to find two that are farther apart than polyester (not at all) and cork (very). In an unexpected twist, however, scientists are figuring out ...

Robotics goes micro-scale

(Phys.org) —The development of light-driven 'micro-robots' that can autonomously investigate and manipulate the nano-scale environment in a microscope comes a step closer, thanks to new research from the ...

Biologists help solve fungi mysteries

(Phys.org) —A new genetic analysis revealing the previously unknown biodiversity and distribution of thousands of fungi in North America might also reveal a previously underappreciated contributor to climate ...