Catching the common cold virus genome

Mar 16, 2009

A new study by Brigham Young University researchers on the virus behind nearly half of all cold infections explains how and where evolution occurs in the rhinovirus genome and what this means for possible vaccines.

The study is reported in the April issue of the academic journal .

"There are a lot of different approaches to treating the cold, none of which seem to be effective," said Keith Crandall, professor of biology and co-author of the study. "This is partly because we haven't spent a lot of time studying the virus and its history to see how it's responding to the human and drugs."

The BYU team studied genomic sequences available online and used computer algorithms to estimate how the rhinovirus is related to other viruses.

According to Nicole Lewis-Rogers, a postdoctoral fellow in the Biology Department and lead author on the study, the rhinovirus is similar to the polio virus, whose vaccine was announced in 1955. But while the polio virus has just three , the rhinovirus has more than 100 subspecies, which continually evolve.

"These viruses could be under the same constraints and yet change differently," Lewis-Rogers said. "That's why it is so hard to create a vaccine."

Through a computer program developed at BYU, Lewis-Rogers' team was able to identify the parts of the that enable resistance to drugs and the human immune system.

The immune system does a good job of recognizing viral contaminants and getting rid of them, as do new drugs, but the rhinovirus has responded to these defenses by changing its genome so that it is not so easily recognized.

"The virus is evolving solutions against the immune system and drugs," Crandall said. "The more we can learn about how the virus evolves solutions, the better we can rid the body of these infections."

Understanding where change occurs in the virus genome will help virologists who work to design drugs that target the rhinovirus.

"If you've got 10,000 bits of information, this narrows it down to a handful," Lewis-Rogers said. "Here is where you can start looking."

Lewis-Rogers and Crandall hope scientists will use these insights to build better drugs to combat the virus in the most effective way.

Source: Brigham Young University (news : web)

Explore further: DNA may have had humble beginnings as nutrient carrier

add to favorites email to friend print save as pdf

Related Stories

Statistical physics shows new approach to fighting viruses

Dec 12, 2005

Computer viruses pose an ongoing threat and their neutralization calls for new strategies, researchers at Tel Aviv University say. Eran Shir and colleagues propose a solution that helps an 'antivirus' program reach an at-risk ...

Recommended for you

DNA may have had humble beginnings as nutrient carrier

16 hours ago

New research intriguingly suggests that DNA, the genetic information carrier for humans and other complex life, might have had a rather humbler origin. In some microbes, a study shows, DNA pulls double duty ...

Central biobank for drug research

16 hours ago

For the development of new drugs it is crucial to work with stem cells, as these allow scientists to study the effects of new active pharmaceutical ingredients. But it has always been difficult to derive ...

User comments : 0