NIST reference materials are 'gold standard' for bio-nanotech research

Jan 09, 2008
NIST reference materials are 'gold standard' for bio-nanotech research
False color scanning electron micrograph (250,000 times magnification) showing the gold nanoparticles created by NIST and the National Cancer Institute's Nanotechnology Characterization Laboratory for use as reference standards in biomedical research laboratories. Credit: Andras Vladar, NIST

The National Institute of Standards and Technology has issued its first reference standards for nanoscale particles targeted for the biomedical research community—literally “gold standards” for labs studying the biological effects of nanoparticles. The three new materials, gold spheres nominally 10, 30 and 60 nanometers in diameter, were developed in cooperation with the National Cancer Institute’s Nanotechnology Characterization Laboratory (NCL).

Nanosized particles are the subject of a great deal of biological research, in part because of concerns that in addition to having unique physical properties due to their size, they also may have unique biological properties. On the negative side, nanoparticles may have special toxicity issues.

On the positive side, they also are being studied as vehicles for targeted drug delivery that have the potential to revolutionize cancer treatments. Research in the field has suffered from a lack of reliable nanoscale measurement standards, both to ensure consistency of data from one lab to the next and to verify the performance of measurement instruments and analytic techniques.

The new NIST reference materials are citrate-stabilized nanosized gold particles in a colloidal suspension in water. They have been extensively analyzed by NIST scientists to assess particle size and size distribution by multiple techniques for dry-deposited, aerosol and liquid-borne forms of the material. Dimensions were measured using six independent methods—including atomic force microscopy (AFM), transmission electron microscopy (TEM), scanning electron microscopy (SEM), differential mobility analysis (DMA), dynamic light scattering (DLS), and small-angle X-ray scattering (SAXS). At the nanoscale in particular, different measurement techniques can and will produce different types of values for the same particles.

In addition to average size and size distributions, the new materials have been chemically analyzed for the concentrations of gold, chloride ion, sodium and citrate, as well as pH, electrical conductivity, and zeta potential (a measure of the stability of the colloidal solution). They have been sterilized with gamma radiation and tested for sterility and endotoxins. Details of the measurement procedures and data are included in a report of investigation accompanying each sample.

Source: National Institute of Standards and Technology

Explore further: Thinnest feasible nano-membrane produced

add to favorites email to friend print save as pdf

Related Stories

Shiny quantum dots brighten future of solar cells

Apr 14, 2014

( —A house window that doubles as a solar panel could be on the horizon, thanks to recent quantum-dot work by Los Alamos National Laboratory researchers in collaboration with scientists from University ...

NASA simulation portrays ozone intrusions from aloft

Apr 10, 2014

( —Outdoor enthusiasts in Colorado's Front Range are occasionally rewarded with remarkable visibility brought about by dry, clear air and wind. But it's what people in the mountainous U.S. West ...

Small, light health patch with enhanced accuracy

Apr 09, 2014

Holst Centre and IMEC have unveiled a prototype flexible health patch weighing just 10g – half the weight of current products. The patch uses real-time electrocardiogram (ECG), tissue-contact impedance ...

Some long non-coding RNAs are conventional after all

Apr 04, 2014

Not so long ago researchers thought that RNAs came in two types: coding RNAs that make proteins and non-coding RNAs that have structural roles. Then came the discovery of small RNAs that opened up whole new areas of research. ...

Astronomers challenge Cosmological Model

Apr 03, 2014

( —Astronomers Professor Chris Collins and Dr Ian McCarthy from LJMU's Astrophysics Research Institute are challenging the view that the currently preferred cosmological model of the Universe is ...

Recommended for you

Making graphene in your kitchen

2 hours ago

Graphene has been touted as a wonder material—the world's thinnest substance, but super-strong. Now scientists say it is so easy to make you could produce some in your kitchen.

Thinnest feasible nano-membrane produced

Apr 17, 2014

A new nano-membrane made out of the 'super material' graphene is extremely light and breathable. Not only can this open the door to a new generation of functional waterproof clothing, but also to ultra-rapid filtration. The ...

Wiring up carbon-based electronics

Apr 17, 2014

Carbon-based nanostructures such as nanotubes, graphene sheets, and nanoribbons are unique building blocks showing versatile nanomechanical and nanoelectronic properties. These materials which are ordered ...

Making 'bucky-balls' in spin-out's sights

Apr 16, 2014

( —A new Oxford spin-out firm is targeting the difficult challenge of manufacturing fullerenes, known as 'bucky-balls' because of their spherical shape, a type of carbon nanomaterial which, like ...

User comments : 0

More news stories

Making graphene in your kitchen

Graphene has been touted as a wonder material—the world's thinnest substance, but super-strong. Now scientists say it is so easy to make you could produce some in your kitchen.