Bladder cells feel stretch

August 7, 2009

Japanese research group led by Prof. Makoto Tominaga and Dr. Takaaki Sokabe (National Institute for Physiological Sciences: NIPS), and Prof. Masayuki Takeda, Dr. Isao Araki and Dr. Tsutomu Mochizuki (Yamanashi Univ.), found that bladder urothelial cells have a sensor for stretch stimulation. Their finding was reported in the Journal of Biological Chemistry published on Aug 7, 2009.

Bladder is known to release ATP that activates micturition reflex pathway during urine storage. However, it has been unknown how urothelial cells sense bladder distension. The research group examined the function of 'TRPV4' protein abundantly expressed in urothelial cells. The group developed a special apparatus to measure cell responses upon stretch stimulation, which mimics bladder distension.

Upon stretch stimulation, robust Ca2+ influx and following ATP release were observed in urothelial cells. These phenomena were almost completely attributed to TRPV4 activation, since such responses were eliminated by a TRPV4 inhibitor and reduced in TRPV4-deficient urothelial cells.

Dr. Sokabe said, "This is the first report to show that TRPV4 is a primal stretch-detector in urothelial cells. Given that TRPV4 is critically involved in the sensing mechanism in the bladder, development of chemicals modulating TRPV4 activity may be useful for treatment of bladder disorders such as overactive and pollakiuria."

Source: National Institute for Physiological Sciences

Explore further: Green tea may protect the bladder from becoming inflamed

Related Stories

Green tea may protect the bladder from becoming inflamed

May 20, 2007

Herbal agents could be used to treat inflammatory bladder diseases, according to a preliminary study that looked at the ability of green tea to protect bladder cells from inflammation. The University of Pittsburgh School ...

Scientists move closer to bio-engineered bladders

August 1, 2007

Researchers at the University of York are using an understanding of the special cells that line the bladder to develop ways of restoring continence to patients with serious bladder conditions, including cancer.

Painful heat sensed by 'painless' in flies

September 30, 2008

Japanese research group led by Prof Makoto Tominaga and Dr Takaaki Sokabe, National Institute for Physiological Sciences (NIPS), Japan, found that a small fly, drosophila, has a receptor for noxious heat. The research group ...

Frankincense oil -- a wise man's remedy for bladder cancer

March 18, 2009

Originating from Africa, India, and the Middle East, frankincense oil has been found to have many medicinal benefits. Now, an enriched extract of the Somalian Frankincense herb Boswellia carteri has been shown to kill off ...

Recommended for you

Yarn from slaughterhouse waste

July 29, 2015

ETH researchers have developed a yarn from ordinary gelatine that has good qualities similar to those of merino wool fibers. Now they are working on making the yarn even more water resistant.

Findings illuminate animal evolution in protein function

July 27, 2015

Virginia Commonwealth University and University of Richmond researchers recently teamed up to explore the inner workings of cells and shed light on the 400–600 million years of evolution between humans and early animals ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.