The latest developmental drugs, particularly for use in oncology, rely on the targeted degradation of harmful pathogenic proteins. In a recent study published in Nature Chemical Biology, researchers at CeMM, the Research ...
Biochemistry
Nov 3, 2022
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32
In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed.
Cell & Microbiology
Oct 6, 2022
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102
Researchers at the Rudolf Virchow Center of the University of Würzburg have unveiled the crystal structures of UBA6 in complex with either ATP or the ubiquitin-like protein FAT10. These results provide the foundation to ...
Cell & Microbiology
Sep 9, 2022
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73
An important function of our cells' signaling pathways is to coordinate growth with environmental cues, such as the availability of nutrients in the cell's environment. Cell growth plays an important role in normal cell function—for ...
Cell & Microbiology
Jul 14, 2022
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441
As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond to the environment and ...
Plants & Animals
Apr 28, 2022
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94
Protein degraders, which induce the protein degradation of target proteins, are expected to be the "next-generation drugs" because they can remove disease-related proteins from cells. Protein degraders, such as thalidomide ...
Molecular & Computational biology
Mar 8, 2022
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19
WEHI researchers have produced the first molecular images of an enzyme that controls proteins to signal and communicate with each other in human cells. The discovery could help to solve the mystery cause of a rare group of ...
Cell & Microbiology
Jan 10, 2022
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96
The molecular mechanism underlying enzyme activity regulation of ubiquitin-specific protease 8 (USP8) has been decoded by researchers at Tokyo Tech. USP8 has been implicated in Cushing's disease pathogenesis. They have identified ...
Molecular & Computational biology
Nov 26, 2021
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73
Scientists have discovered that the protein ubiquitin plays an important role in the regulation of the aging process. Ubiquitin was previously known to control processes such as signal transduction and metabolism. Prof. Dr. ...
Cell & Microbiology
Jul 29, 2021
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1009
Researchers from Osaka University have found that the attachment of a ubiquitin molecule to a protein called PCNA at the lysine 107 position causes gross chromosomal rearrangements. This lysine is located where two PCNA molecules ...
Cell & Microbiology
Jul 22, 2021
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12
