If one imagines the genome as an instruction manual for the functioning of a cell, every page of this manual is covered with annotations, highlights, and bookmarks. The role of some of these marks remains mysterious—do ...
Cell & Microbiology
Feb 20, 2023
0
110
Thanks to high-throughput single-cell RNA sequencing (scRNA-seq), it is possible to construct single-cell transcriptomic atlases at the organic level. For example, cell atlases for vertebrate and invertebrate systems have ...
Cell & Microbiology
Sep 5, 2022
0
10
Researchers at the Francis Crick Institute have uncovered how the double helix structure of DNA is opened to allow DNA replication. The work could lead to further studies to better understand this process including how it ...
Molecular & Computational biology
Jun 16, 2022
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15
Life starts with one cell. When an organism develops, dividing cells specialize to form the variety of tissues and organs that build up the adult body, while keeping the same genetic material—contained in our DNA. In a ...
Molecular & Computational biology
Feb 3, 2022
1
38
In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the mechanism behind regulated ...
Evolution
Nov 19, 2021
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19
Scientists from Tokyo Metropolitan University have uncovered a unique mechanism where two transcription factors stabilize each other's binding to DNA in fission yeast. They found that Atf1 and Rst2 help each other stably ...
Molecular & Computational biology
Sep 13, 2021
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49
The phenomenon of "liquid-liquid" phase separation (LLPS) of biological macromolecules in living cells regulates many cell activities.
Biochemistry
Jul 30, 2021
0
52
The corona pandemic has ensured that the term "mRNA" is now also known to a large public beyond laboratories and lecture halls. However, the molecule is much more than an important component of a successful vaccine against ...
Molecular & Computational biology
Jul 14, 2021
0
8
New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now—precisely how the copying of genetic material that, once started, is properly turned ...
Cell & Microbiology
Nov 26, 2020
8
1789
New insights into what causes neighboring, genetically identical stem cells in mouse embryos to behave differently in terms of the proteins they produce could have implications for regenerative medicine and the early detection ...
Molecular & Computational biology
Sep 25, 2020
0
5
