Learning from nature's bounty: New libraries for drug discovery

Natural products, or their close derivatives, make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. The size and complexity of macrocycles has made it difficult ...

Video: Meet a molecular architect: Hosea Nelson

Speaking of Chemistry visits the University of California at Los Angeles to meet with Hosea Nelson, Ph.D., who is tackling the challenge of total synthesis—the use of chemistry to build any molecule.

Lab simplifies total synthesis of anti-cancer agent

The lab of Rice University synthetic organic chemist K.C. Nicolaou has reported the streamlined total synthesis of delta12-prostaglandin J3, a molecule previously claimed to kill leukemic cancer cells.

Englerin analogues with anti-cancer activity

The research group of Prof. Antonio M. Echavarren at ICIQ has designed and synthetized a series of analogues of (-)-Englerin A that are highly selective and effective in the growth-inhibition of renal cancer cells.

Chemists develop new strategy to synthesize molecule

A team of researchers led by Professor Pauline Chiu from Department of Chemistry, the University of Hong Kong, has successfully achieved a formal total synthesis of cortistatin A, a molecule which could help mitigate the ...

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