Making puffer fish toxin in a flask

In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials ...

Learning from nature's bounty: New libraries for drug discovery

Natural products, or their close derivatives, make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. The size and complexity of macrocycles has made it difficult ...

Video: Meet a molecular architect: Hosea Nelson

Speaking of Chemistry visits the University of California at Los Angeles to meet with Hosea Nelson, Ph.D., who is tackling the challenge of total synthesis—the use of chemistry to build any molecule.

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