New 'radar' detects active cellular destroyers

Cells in the human body must adapt their protein balance to certain situations, such as the availability of iron or an infection. These adaptations occur through a complex process in which proteins that are no longer needed ...

Neural network helps design brand new proteins

With their intricate arrangements and dynamic functionalities, proteins perform a plethora of biological tasks by employing unique arrangements of simple building blocks where geometry is key. Translating this nearly limitless ...

Deciphering the molecular dynamics of complex proteins

Which structures do complex proteins adopt in solution? Konstanz biophysicists answer this question using the example of ubiquitin dimers as well as a new combination of high-resolution NMR spectroscopy and sophisticated ...

New inhibitor for regulating the essential protein SMNDC1

The SMNDC1 gene controls key functions in the human body and is linked to diseases such as diabetes and cancer. Scientists in Stefan Kubicek's research group at the CeMM Research Center for Molecular Medicine of the Austrian ...

Deep learning for new protein design

The key to understanding proteins—such as those that govern cancer, COVID-19, and other diseases—is quite simple: Identify their chemical structure and find which other proteins can bind to them. But there's a catch.

Blue light: An on-off switch for enzymes

Light affects living organisms in many different ways, for example, plants orient their growth direction towards the sun, while circadian rhythms in humans are controlled by daylight. These processes always involve photoreceptors, ...

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